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<p>The quantitative detection of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in waterlogged foods and living cancer cells is important for food safety and clinical detection. In this study, single-atom cobalt catalysts in polymeric carbon nitride (Co SACs-CN) were synthesized by grinding and pyrolysis. This catalyst&#xa0;was subsequently used to modify a pencil graphite electrode (PGE) for electrochemical detection of H<sub>2</sub>O<sub>2</sub>. The electrostatic potential of H<sub>2</sub>O<sub>2</sub> was analyzed using Gaussian and Multiwfn software. The linear range of the prepared electrochemical sensor was 1 − 8000&#xa0;μM, and the detection limit was 0.31&#xa0;μM. After 30&#xa0;days, the current retention rate was 93.4%, which can be used for the electrochemical determination of H<sub>2</sub>O<sub>2</sub> in waterlogged foods. Moreover, the sensor was capable of real-time monitoring of H<sub>2</sub>O<sub>2</sub> release from A549 lung cancer cells. The successful development of this sensor has broadened the application of cobalt-based single-atom nanomaterials in the design of H<sub>2</sub>O<sub>2</sub> sensors and offers a novel alternative for the electrochemical detection of H<sub>2</sub>O<sub>2</sub>.</p> Graphical Abstract <p></p>

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Cobalt single-atom catalyst for hydrogen peroxide electrochemical detection in waterlogged foods and living cancer cells

  • 期刊论文

  • 发表日期：

    2025年5月16日

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  • Ming Wei,
  • Zhichao Ma,
  • Xichen Sun,
  • Yiran Wang,
  • Xuelin Zong,
  • Wenting Tong,
  • Wenbo Lu

摘要

The quantitative detection of hydrogen peroxide (H2O2) in waterlogged foods and living cancer cells is important for food safety and clinical detection. In this study, single-atom cobalt catalysts in polymeric carbon nitride (Co SACs-CN) were synthesized by grinding and pyrolysis. This catalyst was subsequently used to modify a pencil graphite electrode (PGE) for electrochemical detection of H2O2. The electrostatic potential of H2O2 was analyzed using Gaussian and Multiwfn software. The linear range of the prepared electrochemical sensor was 1 − 8000 μM, and the detection limit was 0.31 μM. After 30 days, the current retention rate was 93.4%, which can be used for the electrochemical determination of H2O2 in waterlogged foods. Moreover, the sensor was capable of real-time monitoring of H2O2 release from A549 lung cancer cells. The successful development of this sensor has broadened the application of cobalt-based single-atom nanomaterials in the design of H2O2 sensors and offers a novel alternative for the electrochemical detection of H2O2.

Graphical Abstract