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<p>Zearalenone (ZEN), a prevalent mycotoxin in agricultural crops, poses significant risks to human and animal health due to its bioaccumulation potential within the food chain. In this study, Au@Cu<sub>2</sub>O core–shell nanoparticles with precisely controlled Cu<sub>2</sub>O shell thickness were synthesized through a gold nanoparticle (AuNPs)-mediated self-assembly strategy by modulating the amount of AuNPs. Systematic analysis revealed an inverse correlation between peroxidase-like activity and shell thickness. Consequently, a high-sensitivity colorimetric aptasensor for ZEN detection was developed via the integration of Au@Cu<sub>2</sub>O nanoparticles with ZEN-specific aptamers. The Au@Cu<sub>2</sub>O nanoparticles function as signal amplifiers, while the aptamers provide target specificity. Under optimal conditions, the aptasensor demonstrated a linear dynamic range of 0.0005–5&#xa0;μg/L for ZEN, with colorimetric signal intensities exhibiting exceptional specificity for ZEN, with negligible cross-reactivity to co-occurring mycotoxins (AFB<sub>1</sub>, AFB<sub>2</sub>, OTA, DON, T-2), while achieving stable detection in real agricultural matrices, including wheat flour and cornmeal. Hence, this work not only offers a novel strategy for ZEN monitoring in food but also advances the rational design of core–shell nanomaterials for biosensing applications.</p> Graphical Abstract <p></p>

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Tailoring shell thickness in Au@Cu2O nanoparticles for enhanced mimetic peroxidase activity: a colorimetric aptasensor for zearalenone detection

  • 期刊论文

  • 发表日期：

    2025年5月7日

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  • Junhao Wang,
  • Huifu Ji,
  • Bobo Zhang,
  • Xiaodong Zhu,
  • Yingju Liu,
  • Weidan Chang,
  • Xinhua Xie,
  • Hongshuai Zhu

摘要

Zearalenone (ZEN), a prevalent mycotoxin in agricultural crops, poses significant risks to human and animal health due to its bioaccumulation potential within the food chain. In this study, Au@Cu2O core–shell nanoparticles with precisely controlled Cu2O shell thickness were synthesized through a gold nanoparticle (AuNPs)-mediated self-assembly strategy by modulating the amount of AuNPs. Systematic analysis revealed an inverse correlation between peroxidase-like activity and shell thickness. Consequently, a high-sensitivity colorimetric aptasensor for ZEN detection was developed via the integration of Au@Cu2O nanoparticles with ZEN-specific aptamers. The Au@Cu2O nanoparticles function as signal amplifiers, while the aptamers provide target specificity. Under optimal conditions, the aptasensor demonstrated a linear dynamic range of 0.0005–5 μg/L for ZEN, with colorimetric signal intensities exhibiting exceptional specificity for ZEN, with negligible cross-reactivity to co-occurring mycotoxins (AFB1, AFB2, OTA, DON, T-2), while achieving stable detection in real agricultural matrices, including wheat flour and cornmeal. Hence, this work not only offers a novel strategy for ZEN monitoring in food but also advances the rational design of core–shell nanomaterials for biosensing applications.

Graphical Abstract