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<p>A&#xa0;novel, low-toxicity Ru-Ni-BPY metal–organic framework (MOF) nanomaterial was developed&#xa0;and a simple and sensitive dual-mode "on–off" ferric ions (Fe<sup>3+</sup>) sensing platform based on this material&#xa0;constructed. The dual-mode detection method enabled cross-validation of the electrochemiluminescence (ECL) and fluorescent (FL) signals, enhancing accuracy and effectively minimizing errors. In linear ranges of 0.005–10&#xa0;μM and 0.078–10&#xa0;μM, Fe<sup>3+</sup> can dramatically quench the ECL and FL signals of the Ru-Ni-BPY MOF, with quenching rates of 91.42% and 91.31%, respectively, and detection limits of 0.1&#xa0;nM and 9.3&#xa0;nM, respectively. This&#xa0;ECL method not only achieved efficient detection of Fe<sup>3+</sup> in rat brain microdialysis fluid but also successfully enabled real-time FL detection of Fe<sup>3+</sup> in nude mice. Therefore, this platform has great potential for applications in environmental protection, life sciences, and early disease diagnosis.</p> Graphical abstract <p></p>

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A ruthenium-nickel metal–organic framework incorporating 2,2'-bipyridine- 5,5'-dicarboxylic acid for dual-mode electrochemiluminescence-fluorescence detection of ferric ions

  • 期刊论文

  • 发表日期：

    2025年4月21日

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  • Jing Zhang,
  • Zhaojiang Yin,
  • Wei Xiong,
  • QiQi Fan,
  • Fengyao Yu,
  • Fusheng Liao,
  • Hao Fan,
  • Fei Qu,
  • Qiangqiang Yu

摘要

A novel, low-toxicity Ru-Ni-BPY metal–organic framework (MOF) nanomaterial was developed and a simple and sensitive dual-mode "on–off" ferric ions (Fe3+) sensing platform based on this material constructed. The dual-mode detection method enabled cross-validation of the electrochemiluminescence (ECL) and fluorescent (FL) signals, enhancing accuracy and effectively minimizing errors. In linear ranges of 0.005–10 μM and 0.078–10 μM, Fe3+ can dramatically quench the ECL and FL signals of the Ru-Ni-BPY MOF, with quenching rates of 91.42% and 91.31%, respectively, and detection limits of 0.1 nM and 9.3 nM, respectively. This ECL method not only achieved efficient detection of Fe3+ in rat brain microdialysis fluid but also successfully enabled real-time FL detection of Fe3+ in nude mice. Therefore, this platform has great potential for applications in environmental protection, life sciences, and early disease diagnosis.

Graphical abstract