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<p>Cariprazine (CAR) is an atypical antipsychotic drug used for the treatment of schizophrenia and bipolar disorder. This study presents the development of a novel, highly sensitive electrochemical sensor based on a Ti<sub>3</sub>C<sub>2</sub>@CoAl<sub>2</sub>O<sub>2</sub> nanocomposite–modified glassy carbon electrode (GCE) for the detection of CAR in pharmaceutical and biological samples. The innovative Ti<sub>3</sub>C<sub>2</sub>@CoAl<sub>2</sub>O<sub>2</sub> composite, synthesized and characterized through Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy coupled with energy-dispersive spectroscopy, and thermogravimetric analysis, revealed exceptional structural integrity, morphology, composition, and thermal stability. The electrochemical properties of the modified electrode were evaluated using cyclic voltammetry and electrochemical impedance spectroscopy, demonstrating enhanced conductivity, an increased electroactive surface area, and reduced charge transfer resistance compared to the bare GCE. Differential pulse voltammetry was employed for CAR detection under optimized conditions, yielding a linear range of 0.2–5.6&#xa0;μM with a regression equation <i>I</i><sub>pa</sub> (μA) = 0.133 <i>C</i><sub>CAR</sub> (μM) + 0.09 (<i>R</i><sup>2</sup> = 0.993). The limit of detection and limit of quantification were determined as 0.02&#xa0;µM and 0.07&#xa0;µM, respectively, highlighting the sensor’s high sensitivity. The modified electrode exhibited excellent repeatability with a relative standard deviation&#xa0;(RSD) of = 2.9% and reproducibility (RSD = 2.8%), along with strong selectivity against common interfering substances. The sensor was successfully applied to human blood serum, urine, and CAR tablets, achieving high recovery values (98.52–103.94%), confirming its reliability for real-sample analysis. These findings underline the novelty and potential of the Ti<sub>3</sub>C<sub>2</sub>@CoAl<sub>2</sub>O<sub>2</sub>-modified GCE as a powerful tool for the accurate, selective, and sensitive determination of CAR in clinical and pharmaceutical applications.</p> Graphical Abstract <p></p>

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Highly sensitive electrochemical determination of cariprazine using a novel Ti3C2@CoAl2O4 nanocomposite: application to pharmaceutical and biological sample analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月24日

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  • Elif Naz Öven,
  • Asena Ayse Genc,
  • Nevin Erk,
  • Wiem Bouali,
  • Qamar Salamat,
  • Mustafa Soylak

摘要

Cariprazine (CAR) is an atypical antipsychotic drug used for the treatment of schizophrenia and bipolar disorder. This study presents the development of a novel, highly sensitive electrochemical sensor based on a Ti3C2@CoAl2O2 nanocomposite–modified glassy carbon electrode (GCE) for the detection of CAR in pharmaceutical and biological samples. The innovative Ti3C2@CoAl2O2 composite, synthesized and characterized through Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy coupled with energy-dispersive spectroscopy, and thermogravimetric analysis, revealed exceptional structural integrity, morphology, composition, and thermal stability. The electrochemical properties of the modified electrode were evaluated using cyclic voltammetry and electrochemical impedance spectroscopy, demonstrating enhanced conductivity, an increased electroactive surface area, and reduced charge transfer resistance compared to the bare GCE. Differential pulse voltammetry was employed for CAR detection under optimized conditions, yielding a linear range of 0.2–5.6 μM with a regression equation Ipa (μA) = 0.133 CCAR (μM) + 0.09 (R2 = 0.993). The limit of detection and limit of quantification were determined as 0.02 µM and 0.07 µM, respectively, highlighting the sensor’s high sensitivity. The modified electrode exhibited excellent repeatability with a relative standard deviation (RSD) of = 2.9% and reproducibility (RSD = 2.8%), along with strong selectivity against common interfering substances. The sensor was successfully applied to human blood serum, urine, and CAR tablets, achieving high recovery values (98.52–103.94%), confirming its reliability for real-sample analysis. These findings underline the novelty and potential of the Ti3C2@CoAl2O2-modified GCE as a powerful tool for the accurate, selective, and sensitive determination of CAR in clinical and pharmaceutical applications.

Graphical Abstract