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<p>A&#xa0;screen-printed carbon electrode (SPCE) based on a molecularly imprinted polymer (MIP) technique has been modified&#xa0;to provide detection of erlotinib (ERL). For this purpose, the pyrogallol (PG) monomer in the presence of ERL as an analyte has been electropolymerized on the SPCE surface. The introduced sensor has been characterized through differential pulse voltammetry (DPV), cyclic voltammetry (CV), and field emission scanning electron microscopy (FESEM) methods. The modified SPCE allowed ERL detection in a linear range of 0.05–800&#xa0;nM with a limit of detection (LOD) of 0.016&#xa0;nM. The applicability of modified SPCE was successfully investigated in serum samples. Lastly, for validation, sensor performance was compared with high-performance liquid chromatography (HPLC). The&#xa0;introduced sensor exhibited good application in the biomedical field.</p> Graphical Abstract <p></p>

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Development of a molecularly imprinted electrochemical sensor for erlotinib detection using a modified screen-printed carbon electrode

  • 期刊论文

  • 发表日期：

    2025年2月10日

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  • Saif Ali Ahmed,
  • Mahmoud Roushani,
  • Zahra Mirzaei Karazan

摘要

A screen-printed carbon electrode (SPCE) based on a molecularly imprinted polymer (MIP) technique has been modified to provide detection of erlotinib (ERL). For this purpose, the pyrogallol (PG) monomer in the presence of ERL as an analyte has been electropolymerized on the SPCE surface. The introduced sensor has been characterized through differential pulse voltammetry (DPV), cyclic voltammetry (CV), and field emission scanning electron microscopy (FESEM) methods. The modified SPCE allowed ERL detection in a linear range of 0.05–800 nM with a limit of detection (LOD) of 0.016 nM. The applicability of modified SPCE was successfully investigated in serum samples. Lastly, for validation, sensor performance was compared with high-performance liquid chromatography (HPLC). The introduced sensor exhibited good application in the biomedical field.

Graphical Abstract