Abstract <p>Ce-MOFs with ferrocenedicarboxylic acid ligands (Ce-FcDC) as a bifunctional nanozyme exhibited high peroxidase (POD)-mimicking activity and superoxide dismutase (SOD)-mimicking activity. H₂O₂ was produced from catalytic hydrolysis of peroxymonosulfate (PMS) using Ce-FcDC as a catalyst. The growth of <i>E. coli</i> and <i>S. aureus</i> were synergistically and more effectively suppressed by PMS in the presence of Ce-FcDC, in comparison with the sole use of PMS or Ce-FcDc. Under the catalysis of Ce-FcDC as the POD-mimicking nanozyme, PMS could be activated by Ce-FcDC to produce SO₄^•− and •OH and H₂O₂ from the hydrolysis of PMS was further derivatized to O₂^•− and •OH. Ce-FcDC as the SOD-mimicking nanozyme causes&#xa0;O₂^•−&#xa0;to&#xa0;form H₂O₂. The generation of O₂^•− and •OH were confirmed using p-benzoquinone and isopropanol alcohol as the scavengers. The resulted SO₄^•−, O₂^•−, and •OH from combination of PMS with Ce-FcDC as an activator may have key roles for suppressing the growth of <i>E. coli</i> and <i>S. aureus</i>. This strategy could be an effective approach for suppressing the growth and preventing infections or pollutions of some other microbial cells as well.</p> Graphical abstract <p></p>