Fluorescence turn-off detection of myoglobin as a cardiac biomarker using water-stable L-glutamic acid functionalized cesium lead bromide perovskite quantum dots

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发表日期：

2024年10月16日

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Bhargava Thamminana,
Mayurkumar Revabhai Patel,
Madhura Pradeep Deshpande,
Tae Jung Park,
Suresh Kumar Kailasa

摘要

Water dispersible L-glutamic acid (Glu) functionalized cesium lead bromide perovskite quantum dots (CsPbBr₃ PQDs), namely CsPbBr₃@Glu PQDs were synthesized and used for the fluorescence “turn-off” detection of myoglobin (Myo). The as-prepared CsPbBr₃@Glu PQDs exhibited an exceptional photoluminescence quantum yield of 25% and displayed emission peak at 520 nm when excited at 380 nm. Interestingly, the fluorescence “turn-off” analytical approach was designed to detect Myo using CsPbBr₃@Glu PQDs as a simple optical probe. The developed probe exhibited a wide linear range (0.1–25 µM) and a detection limit of 42.42 nM for Myo sensing. The CsPbBr₃@Glu PQDs-based optical probe provides high ability to determine Myo in serum and plasma samples.

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