A photoelectrochemical aptasensing platform assembled at the heterojunction interface of Cu₃BiS₃ sensitized CuV₂O₆ for bisphenol A

The interaction between the sensitive interfaces of photoelectrochemical (PEC) semiconductor nanomaterials and microscopic matter creates endless potential for the efficient detection of endocrine disruptor. This work presents the development of a high-efficiency PEC aptasensor for bisphenol A (BPA) monitoring based on Cu₃BiS₃ sensitized CuV₂O₆ nanocomposites with exceptional visible-light PEC activity. We implemented the integration of Cu₃BiS₃ nanosheet photosensitizer to sensitize the CuV₂O₆ nanowire structure that was synthesized utilizing a facile hydrothermal approach. The band gap alignment between Cu₃BiS₃ and CuV₂O₆ facilitated enduring PEC response yielding an efficient interfacial structure. The surface of the CuV₂O₆/Cu₃BiS₃ electrode was modified with BPA aptamer, enabling specific binding with BPA and precise quantification of its content. The developed aptamer sensors possess a wide detection range of 5.00 × 10⁻¹ to 5.00 × 10⁴ ng/mL, and a low detection limit of 1.60 × 10⁻¹ ng/mL (at S/N = 3). After undergoing 20 testing cycles and enduring long-term storage, the sensor maintained its stability and showcased excellent repeatability and reproducibility. This study presents a promising methodology for the detection of BPA in environmental settings.