<p>In this paper, we explore quantum dynamics of relativistic quantum oscillator field within the framework of generalized Klein-Gordon oscillator in the context of four-dimensional wormhole with a cosmic string. The considered space-time is an example of Morris-Thorne-type traversable wormhole with topological defect. We derive a radial second-order differential equation of the generalized Klein-Gordon oscillator equation and obtain analytical solution through special functions by choosing different potential functions. In this study, we consider two distinct functions: a Coulomb- and Cornell-like potential form and solve the differential equation. As particular case, we presented the ground state energy level and the corresponding wave function of quantum oscillator fields. In fact, it is shown that the wormhole throat radius and cosmic string influences the eigenvalue solution compared to flat space results. The presence of topological defect of cosmic string breaks the degeneracy of the spectra of energy.</p>