Scholarlink

Purpose <p>This study aimed to determine the risk factors for new-onset hepatic steatosis after total pancreatectomy (TP), focusing on muscle loss and sex.</p> Methods <p>We retrospectively analyzed 100 patients who underwent TP between 2005 and 2024. Nutritional parameters, BMI, muscle volume, and liver status were evaluated. Logistic regression and subgroup analyses were performed to identify the risk factors for hepatic steatosis.</p> Results <p>The prevalence of hepatic steatosis increased from 3.0% preoperatively to 24.0% at 3–6 months after TP. Female patients showed a significantly higher incidence of hepatic steatosis than male patients (37.8% vs. 12.7%, respectively). A multivariate analysis identified female sex (odds ratio: 7.77, 95% confidence interval: 2.03–29.8, <i>p</i> = 0.009), younger age (0.93, 0.88–0.98, 0.011), and higher preoperative BMI (1.28, 1.05–1.63, 0.015) as independent risk factors. Among the female patients, a younger age, one-stage TP, greater reductions in SMI, portal vein resection, longer operative time, greater blood loss, and diarrhea at discharge were associated with new-onset hepatic steatosis. However, a lower intraoperative blood loss potentially contributes to recovery from hepatic steatosis after TP.</p> Conclusions <p>A female sex is a high risk factor for hepatic steatosis after TP. Reducing operative stress and preserving muscle volume may facilitate the prevention and recovery from hepatic steatosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of reduction in skeletal muscle quantity and sex differences on postoperative hepatic steatosis following total pancreatectomy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月29日

查看全文
  • Mitsuhiro Shimura,
  • Masamichi Mizuma,
  • Shimpei Maeda,
  • Fuyuhiko Motoi,
  • Mika Ando,
  • Yuichiro Umino,
  • Hideaki Sato,
  • Shuichi Aoki,
  • Koetsu Inoue,
  • Masahiro Iseki,
  • Daisuke Douchi,
  • Takayuki Miura,
  • Masaharu Ishida,
  • Takashi Kamei,
  • Michiaki Unno

摘要

Purpose

This study aimed to determine the risk factors for new-onset hepatic steatosis after total pancreatectomy (TP), focusing on muscle loss and sex.

Methods

We retrospectively analyzed 100 patients who underwent TP between 2005 and 2024. Nutritional parameters, BMI, muscle volume, and liver status were evaluated. Logistic regression and subgroup analyses were performed to identify the risk factors for hepatic steatosis.

Results

The prevalence of hepatic steatosis increased from 3.0% preoperatively to 24.0% at 3–6 months after TP. Female patients showed a significantly higher incidence of hepatic steatosis than male patients (37.8% vs. 12.7%, respectively). A multivariate analysis identified female sex (odds ratio: 7.77, 95% confidence interval: 2.03–29.8, p = 0.009), younger age (0.93, 0.88–0.98, 0.011), and higher preoperative BMI (1.28, 1.05–1.63, 0.015) as independent risk factors. Among the female patients, a younger age, one-stage TP, greater reductions in SMI, portal vein resection, longer operative time, greater blood loss, and diarrhea at discharge were associated with new-onset hepatic steatosis. However, a lower intraoperative blood loss potentially contributes to recovery from hepatic steatosis after TP.

Conclusions

A female sex is a high risk factor for hepatic steatosis after TP. Reducing operative stress and preserving muscle volume may facilitate the prevention and recovery from hepatic steatosis.