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Purpose <p>This study aimed to investigate the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and long-term prognosis and postoperative complications in older patients with colorectal cancer (CRC).</p> Methods <p>Three hundred three patients with pathological stage (pStage) I-III CRC who underwent curative surgery at our institution between 2015 and 2022 were retrospectively analyzed. Patients aged ≥ 75 years were defined as older.</p> Results <p>In the overall cohort, a low CALLY index was an independent prognostic factor (hazard ratio (HR) = 2.42, 95% confidence interval (CI): 1.31–4.47, <i>p</i> = 0.004). The age-stratified analysis revealed that a low CALLY index was associated with a worse prognosis and was an independent prognostic factor in older patients (HR = 3.46, 95% CI: 1.44–8.30, <i>p</i> = 0.005), whereas no independent prognostic significance was observed in non-older patients. Moreover, although the CALLY index was not associated with postoperative complications in non-older patients, a low CALLY index was an independent risk factor for postoperative complications in older patients (odds ratio = 3.93, 95% CI 1.49–10.3, <i>p</i> = 0.005).</p> Conclusion <p>The CALLY index is a valuable predictor of both short- and long-term outcomes in patients with pStage I-III CRC, with a particularly strong impact on older patients aged ≥ 75 years.</p>

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Clinical significance of the C-reactive protein-albumin-lymphocyte index in older patients with colorectal cancer

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Daiki Matsubara,
  • Miki Tanaka,
  • Atsuhito Ando,
  • Atsushi Matsumura,
  • Satoshi Mochizuki,
  • Koji Miyagawa,
  • Nobuaki Fuji,
  • Atsushi Shiozaki

摘要

Purpose

This study aimed to investigate the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and long-term prognosis and postoperative complications in older patients with colorectal cancer (CRC).

Methods

Three hundred three patients with pathological stage (pStage) I-III CRC who underwent curative surgery at our institution between 2015 and 2022 were retrospectively analyzed. Patients aged ≥ 75 years were defined as older.

Results

In the overall cohort, a low CALLY index was an independent prognostic factor (hazard ratio (HR) = 2.42, 95% confidence interval (CI): 1.31–4.47, p = 0.004). The age-stratified analysis revealed that a low CALLY index was associated with a worse prognosis and was an independent prognostic factor in older patients (HR = 3.46, 95% CI: 1.44–8.30, p = 0.005), whereas no independent prognostic significance was observed in non-older patients. Moreover, although the CALLY index was not associated with postoperative complications in non-older patients, a low CALLY index was an independent risk factor for postoperative complications in older patients (odds ratio = 3.93, 95% CI 1.49–10.3, p = 0.005).

Conclusion

The CALLY index is a valuable predictor of both short- and long-term outcomes in patients with pStage I-III CRC, with a particularly strong impact on older patients aged ≥ 75 years.