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Background <p>Neoadjuvant chemotherapy (NAC) is the standard treatment for advanced esophageal squamous cell carcinoma (ESCC). However, larger ESCCs leading to cancerous esophageal stenosis show a poor response to NAC. Therefore, this study aimed to evaluate the efficacy of NAC in patients with cancerous esophageal stenosis.</p> Methods <p>Between April 2011 and March 2022, 71 patients with ESCC and esophageal stenosis underwent minimally invasive esophagectomy (MIE) at Kobe University Hospital and Hyogo Cancer Center. In the NAC followed by surgery (NAC) group (<i>n</i> = 30), patients received cisplatin plus 5-fluorouracil (CF). Enteral nutrition was administered via a nasogastric tube during NAC. In the Upfront Surgery group (<i>n</i> = 41), patients in a good condition after surgery received CF therapy. Propensity score matching was used to identify 24 matched patients in each group.</p> Results <p>After propensity score matching, no significant differences were observed in the background factors; however, patients in the NAC group tended to have a slightly worse overall survival than those in the Upfront Surgery group (<i>p</i> = 0.056).</p> Conclusion <p>No improvement in the overall survival was reported after preoperative CF therapy and enteral nutrition. Therefore, upfront surgery and postoperative chemotherapy may provide a better alternative treatment for these patients.</p>

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Preoperative chemotherapy and enteral nutrition via a nasogastric tube do not improve preoperative nutritional status and survival outcomes for thoracic esophageal squamous cell carcinoma with esophageal stenosis

  • 期刊论文

  • 发表日期：

    2026年4月10日

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  • Yasufumi Koterazawa,
  • Hironobu Goto,
  • Tomoko Tanaka,
  • Tomoaki Aoki,
  • Yutaka Sugita,
  • Taro Ikeda,
  • Hitoshi Harada,
  • Yasunori Otowa,
  • Naoki Urakawa,
  • Hiroshi Hasegawa,
  • Shingo Kanaji,
  • Takeru Matsuda,
  • Tetsu Nakamura,
  • Yoshihiro Kakeji

摘要

Background

Neoadjuvant chemotherapy (NAC) is the standard treatment for advanced esophageal squamous cell carcinoma (ESCC). However, larger ESCCs leading to cancerous esophageal stenosis show a poor response to NAC. Therefore, this study aimed to evaluate the efficacy of NAC in patients with cancerous esophageal stenosis.

Methods

Between April 2011 and March 2022, 71 patients with ESCC and esophageal stenosis underwent minimally invasive esophagectomy (MIE) at Kobe University Hospital and Hyogo Cancer Center. In the NAC followed by surgery (NAC) group (n = 30), patients received cisplatin plus 5-fluorouracil (CF). Enteral nutrition was administered via a nasogastric tube during NAC. In the Upfront Surgery group (n = 41), patients in a good condition after surgery received CF therapy. Propensity score matching was used to identify 24 matched patients in each group.

Results

After propensity score matching, no significant differences were observed in the background factors; however, patients in the NAC group tended to have a slightly worse overall survival than those in the Upfront Surgery group (p = 0.056).

Conclusion

No improvement in the overall survival was reported after preoperative CF therapy and enteral nutrition. Therefore, upfront surgery and postoperative chemotherapy may provide a better alternative treatment for these patients.