Purpose <p>Acute appendicitis is among the most common causes of emergency department visits requiring urgent surgery, with an annual incidence of approximately 100 cases per 100,000 people. This high incidence substantially increases the hospital workload and healthcare costs, prompting the investigation of alternative management strategies. This study aimed to evaluate the clinical reliability of same-day discharge after laparoscopic appendectomy by analyzing the postoperative complications, rehospitalization, and economic outcomes.</p> Methods <p>Patients with uncomplicated acute appendicitis treated between January 2023 and October 2024 were included. The patients discharged within the first 12&#xa0;h after surgery were assigned to Group 1, whereas those discharged after 24&#xa0;h were assigned to Group 2.</p> Results <p>Post-discharge complications occurred in two (1.8%) patients in Group 1 and four (3.6%) in Group 2. No significant difference was observed between the groups in terms of post-discharge emergency department visits, which occurred in 6.3% (<i>n</i> = 7) of Group 1 and 9.8% (<i>n</i> = 11) of Group 2. The non-surgical costs were significantly lower in the same-day discharge group, with a median cost of $87.50 (44–213), compared with $256.50 (82–1,260) in the control group (<i>p</i> &lt; 0.001).</p> Conclusions <p>Same-day discharge after laparoscopic appendectomy does not increase postoperative complications, emergency department visits, or hospital readmissions. This approach is safe, cost-effective, and feasible in routine clinical practice. Additionally, same-day discharge enables postoperative management and discharge of up to three patients with acute appendicitis within 24&#xa0;h using a single service bed.</p>