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Purpose <p>Although surgical treatment can benefit older adults with gastric cancer (GC), the optimal surgical strategies for this population remain uncertain. We evaluated whether a 10-item frailty index based on comprehensive geriatric assessment (FI-CGA-10) could predict the postoperative outcomes of older adults undergoing gastrectomy for GC.</p> Methods <p>The subjects of this retrospective cohort study were patients aged ≥ 75 years who underwent CGA prior to curative gastrectomy. Patients were classified as fit, pre-frail, or frail according to FI-CGA-10 scores. We analyzed the associations between frailty status (frail vs. fit/pre-frail), screening tools, postoperative complications (Clavien–Dindo grade ≥ 2), treatment patterns, and follow-up outcomes.</p> Results <p>Among 79 patients, 18 were classified as frail and 61, as fit or pre-frail. Despite undergoing less extensive surgery, the frail group had more postoperative complications (50% vs. 23%, <i>P</i> = 0.032). Multivariable analysis showed that frailty was independently associated with complications (odds ratio = 4.86; 95% CI, 1.22–19.3; <i>P</i> = 0.025). The frail group also had longer hospitalizations, less adjuvant chemotherapy, and more frequent discontinuation of postoperative surveillance.</p> Conclusion <p>FI-CGA-10 was associated with postoperative complications in older adults undergoing gastrectomy for GC and may be useful for preoperative risk stratification.</p>

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Frailty assessed by comprehensive geriatric assessment and postoperative outcomes of older adults undergoing gastrectomy for gastric cancer

  • 期刊论文

  • 发表日期：

    2026年3月19日

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  • Yuta Kasagi,
  • Tomohiro F. Nishijima,
  • Rena Yokomizo,
  • Munehide Terashi,
  • Ayako Iwanaga,
  • Naomichi Koga,
  • Masahiko Sugiyama,
  • Yasue Kimura,
  • Masaru Morita

摘要

Purpose

Although surgical treatment can benefit older adults with gastric cancer (GC), the optimal surgical strategies for this population remain uncertain. We evaluated whether a 10-item frailty index based on comprehensive geriatric assessment (FI-CGA-10) could predict the postoperative outcomes of older adults undergoing gastrectomy for GC.

Methods

The subjects of this retrospective cohort study were patients aged ≥ 75 years who underwent CGA prior to curative gastrectomy. Patients were classified as fit, pre-frail, or frail according to FI-CGA-10 scores. We analyzed the associations between frailty status (frail vs. fit/pre-frail), screening tools, postoperative complications (Clavien–Dindo grade ≥ 2), treatment patterns, and follow-up outcomes.

Results

Among 79 patients, 18 were classified as frail and 61, as fit or pre-frail. Despite undergoing less extensive surgery, the frail group had more postoperative complications (50% vs. 23%, P = 0.032). Multivariable analysis showed that frailty was independently associated with complications (odds ratio = 4.86; 95% CI, 1.22–19.3; P = 0.025). The frail group also had longer hospitalizations, less adjuvant chemotherapy, and more frequent discontinuation of postoperative surveillance.

Conclusion

FI-CGA-10 was associated with postoperative complications in older adults undergoing gastrectomy for GC and may be useful for preoperative risk stratification.