Scholarlink

Purpose <p>This study aimed to investigate the prognostic impact of preoperative indicators that reflect systemic inflammatory, nutritional, and immune status, focusing on the C-reactive protein–albumin–lymphocyte (CALLY) index in patients undergoing surgery for pancreatic ductal adenocarcinoma.</p> Methods <p>This retrospective study included 120 patients (stage I = 19, II = 94, III = 7) who underwent surgical resection for pancreatic ductal adenocarcinoma between 2007 and 2019. Preoperative laboratory data and the CALLY index were collected to evaluate their impact on overall survival (OS). A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cutoff values.</p> Results <p>The optimal cutoff value for the preoperative CALLY index was 4.0. Patients with a low CALLY index (&lt; 4.0) demonstrated a significantly worse OS than those with a high CALLY index (≥ 4.0) (<i>P</i> = 0.001). A multivariate analysis of composite indices identified low CALLY index (<i>P</i> = 0.001) as an independent prognostic factor, along with positive lymph node metastasis (<i>P</i> = 0.035) and the absence of adjuvant chemotherapy (<i>P</i> = 0.005).</p> Conclusion <p>The CALLY index reflects the preoperative systemic inflammatory, nutritional, and immune status. It is a convenient and practical prognostic predictor of OS in patients undergoing surgery for pancreatic ductal adenocarcinoma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preoperative low C-reactive protein–albumin–lymphocyte (CALLY) index is a poor prognostic indicator for overall survival in patients undergoing surgery for pancreatic ductal adenocarcinoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月19日

查看全文
  • Yu Matsumoto,
  • Yuichiro Otsuka,
  • Hiroka Hosaka,
  • Yoji Kajiwara,
  • Rei Okada,
  • Yuko Ito,
  • Masaru Tsuchiya,
  • Hideaki Shimada

摘要

Purpose

This study aimed to investigate the prognostic impact of preoperative indicators that reflect systemic inflammatory, nutritional, and immune status, focusing on the C-reactive protein–albumin–lymphocyte (CALLY) index in patients undergoing surgery for pancreatic ductal adenocarcinoma.

Methods

This retrospective study included 120 patients (stage I = 19, II = 94, III = 7) who underwent surgical resection for pancreatic ductal adenocarcinoma between 2007 and 2019. Preoperative laboratory data and the CALLY index were collected to evaluate their impact on overall survival (OS). A receiver operating characteristic (ROC) curve analysis was used to identify the optimal cutoff values.

Results

The optimal cutoff value for the preoperative CALLY index was 4.0. Patients with a low CALLY index (< 4.0) demonstrated a significantly worse OS than those with a high CALLY index (≥ 4.0) (P = 0.001). A multivariate analysis of composite indices identified low CALLY index (P = 0.001) as an independent prognostic factor, along with positive lymph node metastasis (P = 0.035) and the absence of adjuvant chemotherapy (P = 0.005).

Conclusion

The CALLY index reflects the preoperative systemic inflammatory, nutritional, and immune status. It is a convenient and practical prognostic predictor of OS in patients undergoing surgery for pancreatic ductal adenocarcinoma.