Scholarlink

Introduction <p>As the global population ages, older patients undergo pancreatoduodenectomy (PD). This study aimed to evaluate the safety and postoperative outcomes of PD in patients &gt; 85&#xa0;years of age.</p> Methods <p>We reviewed 200 consecutive PDs and compared the postoperative outcomes in patients aged ≥ 85&#xa0;years using propensity score matching (PSM).</p> Results <p>After PSM, no differences in the clinical characteristics were observed between the two cohorts (n = 16 each). Those aged ≥ 85&#xa0;years had a significantly lower induction rate of adjuvant chemotherapy (p &lt; 0.0001) and a higher rate of best supportive care selection at recurrence (BSC) (p = 0.033) than those aged &lt; 85&#xa0;years. There was no significant difference in the rate of non-cancer-related deaths (p = 0.18). Although there were no significant differences in the -free survival rates (p = 0.89), the overall survival rate of those ≥ 85&#xa0;years was significantly worse (p = 0.023). The risk factors for death after surgery were tumor-related factors and BSC (p = 0.0012). An age ≥ 85&#xa0;years was not a risk factor for major postoperative complications or death after surgery.</p> Conclusions <p>PD can be safely performed in patients aged ≥ 85&#xa0;years without increasing postoperative complications and recurrences in the cases with appropriate patient selection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Postoperative outcomes of pancreatoduodenectomy for pancreatic head malignancy in patients over 85 years of age: A safety evaluation using propensity score matching

  • 期刊论文

  • 发表日期：

    2026年2月9日

查看全文
  • Shohei Yoshiya,
  • Yo-ichi Yamashita,
  • Naotaka Inomata,
  • Ippei Kawada,
  • Sota Nakamura,
  • Kazuhiro Tada,
  • Yosuke Kuroda,
  • Kentaro Iwaki,
  • Kengo Fukuzawa,
  • Tomoharu Yoshizumi

摘要

Introduction

As the global population ages, older patients undergo pancreatoduodenectomy (PD). This study aimed to evaluate the safety and postoperative outcomes of PD in patients > 85 years of age.

Methods

We reviewed 200 consecutive PDs and compared the postoperative outcomes in patients aged ≥ 85 years using propensity score matching (PSM).

Results

After PSM, no differences in the clinical characteristics were observed between the two cohorts (n = 16 each). Those aged ≥ 85 years had a significantly lower induction rate of adjuvant chemotherapy (p < 0.0001) and a higher rate of best supportive care selection at recurrence (BSC) (p = 0.033) than those aged < 85 years. There was no significant difference in the rate of non-cancer-related deaths (p = 0.18). Although there were no significant differences in the -free survival rates (p = 0.89), the overall survival rate of those ≥ 85 years was significantly worse (p = 0.023). The risk factors for death after surgery were tumor-related factors and BSC (p = 0.0012). An age ≥ 85 years was not a risk factor for major postoperative complications or death after surgery.

Conclusions

PD can be safely performed in patients aged ≥ 85 years without increasing postoperative complications and recurrences in the cases with appropriate patient selection.