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Purpose <p>Most cases of postoperative non-small-cell lung cancer (NSCLC) recurrence occur within 5 years of curative resection, with rare cases of late recurrence occurring after 5 years. However, the unique characteristics of late recurrence remain unclear. This study aimed to elucidate the characteristics and risk factors for late recurrence in patients with NSCLC.</p> Methods <p>We retrospectively analyzed 693 patients who underwent curative resection for NSCLC between 2004 and 2013. The primary endpoint was the identification of risk factors for late recurrence, that is, recurrence 5 years after resection.</p> Results <p>The 5- and 10-year overall survival (OS) rates were 80.6% and 63.7%, respectively. Among the 435 patients who were recurrence-free for 5 years postoperatively, late recurrence occurred in 24(5.5%). A multivariate analysis identified age at resection (≥ 75 years) as a significant risk factor for late recurrence. Post-recurrence survival did not differ between patients with recurrence within five years and those with late recurrence.</p> Conclusions <p>Age at resection (≥ 75 years) was a potential risk factor for late NSCLC recurrence. These patients require long-term follow-up and monitoring for up to five years after resection.</p>

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Predictors and characteristics of late recurrence in non-small cell lung cancer patients 5 years or more after complete resection

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Dai Sonoda,
  • Raito Maruyama,
  • Yasuto Kondo,
  • Masahito Naito,
  • Masash Mikubo,
  • Kazu Shiomi,
  • Yukitoshi Satoh

摘要

Purpose

Most cases of postoperative non-small-cell lung cancer (NSCLC) recurrence occur within 5 years of curative resection, with rare cases of late recurrence occurring after 5 years. However, the unique characteristics of late recurrence remain unclear. This study aimed to elucidate the characteristics and risk factors for late recurrence in patients with NSCLC.

Methods

We retrospectively analyzed 693 patients who underwent curative resection for NSCLC between 2004 and 2013. The primary endpoint was the identification of risk factors for late recurrence, that is, recurrence 5 years after resection.

Results

The 5- and 10-year overall survival (OS) rates were 80.6% and 63.7%, respectively. Among the 435 patients who were recurrence-free for 5 years postoperatively, late recurrence occurred in 24(5.5%). A multivariate analysis identified age at resection (≥ 75 years) as a significant risk factor for late recurrence. Post-recurrence survival did not differ between patients with recurrence within five years and those with late recurrence.

Conclusions

Age at resection (≥ 75 years) was a potential risk factor for late NSCLC recurrence. These patients require long-term follow-up and monitoring for up to five years after resection.