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Purposes <p>The symptoms of low anterior resection syndrome (LARS) are diverse, and its ambiguous definition has made estimating its prevalence difficult. In 2018, an international consensus proposed a new LARS definition based on eight symptoms and consequences. We conducted this study to evaluate the prevalence of LARS, using this new definition (LARS-ND), and to identify its risk factors.</p> Methods <p>This multicenter, cross-sectional study surveyed patients who underwent curative resection for rectal tumors between 2020 and 2022 at 10 institutions. A one-time questionnaire based on the new LARS definition was distributed. Outcomes included LARS-ND prevalence and risk factors.</p> Results <p>A total of 343 patients responded (response rate: 86.6%). The prevalence of LARS-ND was 72.5%, with no significant differences across groups with different follow-up durations. The most frequent symptom and consequence were “emptying difficulties” (93.3%) and “the need for strategies and compromises” (47.5%). Among patients categorized as having “no LARS” by the conventional score, 25% were diagnosed with LARS-ND. Multivariate analysis identified younger age (&lt; 70 years; OR = 2.28) and short anastomosis distance (≤ 5&#xa0;cm; OR = 1.96) as risk factors.</p> Conclusions <p>The prevalence of LARS-ND was high, and the new LARS definition identified patients with symptoms previously missed by the conventional score. Younger age and a lower anastomosis level appear to be risk factors for LARS-ND.</p>

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Prevalence of and risk factors for low anterior resection syndrome based on the international consensus definition: a multicenter cross-sectional observational study

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Yosuke Atsumi,
  • Masakatsu Numata,
  • Koji Numata,
  • Manabu Shiozawa,
  • Keisuke Kazama,
  • Sho Sawazaki,
  • Atsuhiko Sugiyama,
  • Hiroyuki Mushiake,
  • Nobuhiro Sugano,
  • Teni Godai,
  • Yusuke Katayama,
  • Akio Higuchi,
  • Mamoru Uchiyama,
  • Yo Mikayama,
  • Kentaro Saito,
  • Takashi Komura,
  • Aya Saito

摘要

Purposes

The symptoms of low anterior resection syndrome (LARS) are diverse, and its ambiguous definition has made estimating its prevalence difficult. In 2018, an international consensus proposed a new LARS definition based on eight symptoms and consequences. We conducted this study to evaluate the prevalence of LARS, using this new definition (LARS-ND), and to identify its risk factors.

Methods

This multicenter, cross-sectional study surveyed patients who underwent curative resection for rectal tumors between 2020 and 2022 at 10 institutions. A one-time questionnaire based on the new LARS definition was distributed. Outcomes included LARS-ND prevalence and risk factors.

Results

A total of 343 patients responded (response rate: 86.6%). The prevalence of LARS-ND was 72.5%, with no significant differences across groups with different follow-up durations. The most frequent symptom and consequence were “emptying difficulties” (93.3%) and “the need for strategies and compromises” (47.5%). Among patients categorized as having “no LARS” by the conventional score, 25% were diagnosed with LARS-ND. Multivariate analysis identified younger age (< 70 years; OR = 2.28) and short anastomosis distance (≤ 5 cm; OR = 1.96) as risk factors.

Conclusions

The prevalence of LARS-ND was high, and the new LARS definition identified patients with symptoms previously missed by the conventional score. Younger age and a lower anastomosis level appear to be risk factors for LARS-ND.