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Purpose <p>To identify the prognostic factors that can define biologically borderline resectable pancreatic cancer (BRPC) in resectable pancreatic cancer (RPC) patients.</p> Methods <p>This retrospective study included 121 R/BRPC patients who underwent upfront surgery. Univariate and multivariate analyses were conducted to investigate the relationship between preoperative factors and overall survival (OS) for RPC. The OS of RPC patients was stratified based on a score, with each independent prognostic factor receiving 1 point. The OS of the R/BRPC patients was compared based on their scores.</p> Results <p>Overall, 113 and eight patients had RPC and BRPC. Serum CA19-9 &gt; 500&#xa0;U/mL (<i>p</i> = 0.048), maximum tumor diameter &gt; 30&#xa0;mm (<i>p</i> = 0.01), superior mesenteric/portal vein contact &lt; 180° (<i>p</i> = 0.04), and minimum apparent diffusion coefficient (ADC<sub>min</sub>) ≤ 1020 × 10<sup>–6</sup>&#xa0;mm<sup>2</sup>/s (<i>p</i> = 0.01) were identified as independent prognostic factors in RPC patients. RPC patients with a score of 0 had a significantly better prognosis than those with scores of 1 and 2–4 and BRPC patients (median OS: 99.3, 35.1, 19.0, and 8.4&#xa0;months; <i>p</i> = 0.007, <i>p</i> &lt; 0.001, and p = 0.003, respectively). No significant difference in the prognosis was observed between BRPC and RPC patients with scores of 1 and 2–4.</p> Conclusions <p>Preoperative ADC<sub>min</sub> in RPC may be a new prognostic factor for biological BRPC.</p>

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The minimum apparent diffusion coefficient value on preoperative magnetic resonance imaging in resectable pancreatic cancer: a new prognostic factor for biologically borderline resectable pancreatic cancer

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Michinori Matsumoto,
  • Masashi Tsunematsu,
  • Ryoga Hamura,
  • Koichiro Haruki,
  • Kenei Furukawa,
  • Yoshihiro Shirai,
  • Tadashi Uwagawa,
  • Shinji Onda,
  • Tomohiko Taniai,
  • Yoshiaki Tanji,
  • Mitsuru Yanagaki,
  • Toru Ikegami

摘要

Purpose

To identify the prognostic factors that can define biologically borderline resectable pancreatic cancer (BRPC) in resectable pancreatic cancer (RPC) patients.

Methods

This retrospective study included 121 R/BRPC patients who underwent upfront surgery. Univariate and multivariate analyses were conducted to investigate the relationship between preoperative factors and overall survival (OS) for RPC. The OS of RPC patients was stratified based on a score, with each independent prognostic factor receiving 1 point. The OS of the R/BRPC patients was compared based on their scores.

Results

Overall, 113 and eight patients had RPC and BRPC. Serum CA19-9 > 500 U/mL (p = 0.048), maximum tumor diameter > 30 mm (p = 0.01), superior mesenteric/portal vein contact < 180° (p = 0.04), and minimum apparent diffusion coefficient (ADCmin) ≤ 1020 × 10–6 mm2/s (p = 0.01) were identified as independent prognostic factors in RPC patients. RPC patients with a score of 0 had a significantly better prognosis than those with scores of 1 and 2–4 and BRPC patients (median OS: 99.3, 35.1, 19.0, and 8.4 months; p = 0.007, p < 0.001, and p = 0.003, respectively). No significant difference in the prognosis was observed between BRPC and RPC patients with scores of 1 and 2–4.

Conclusions

Preoperative ADCmin in RPC may be a new prognostic factor for biological BRPC.