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Purpose <p>To assess the usefulness of and predictive factors for pleurodesis using 50% glucose solution to treat air leak after pulmonary resection.</p> Methods <p>The subjects of this retrospective study were 70 patients from three Japanese institutions, who were treated with 50% glucose solution for postoperative air leak between April, 2015 and March, 2023. Air leak was monitored using a digital drainage system. We analyzed the patient characteristics, surgical details, and outcomes. Successful pleurodesis was defined as control of the air leak within two attempts and no recurrence within 1&#xa0;month after drain removal. Predictors of success were identified using multivariable logistic regression.</p> Results <p>Pleurodesis with 50% glucose solution treated air leak successfully in 58 patients (83%), with a median time from resection to pleurodesis of 4&#xa0;days. Air leak control was achieved within 2&#xa0;days in 93% of these patients. Air leak volume &lt; 300&#xa0;mL/min before pleurodesis and an air space rate &lt; 10% calculated on chest radiograph were independent predictors of success. The success rate for patients with both or none of these factors was 97% and 29%, respectively. No life-threatening complications were observed.</p> Conclusions <p>Pleurodesis using 50% glucose solution could be useful for managing postoperative air leak, especially in patients with an air leak volume &lt; 300&#xa0;mL/min and an air space rate &lt; 10%.</p>

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Pleurodesis using 50% glucose solution for air leak after pulmonary resection: a multi-center retrospective study

  • 期刊论文

  • 发表日期：

    2025年4月26日

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  • Ryosuke Tokuda,
  • Satoru Okada,
  • Yasuo Ueshima,
  • Satoshi Ikebe,
  • Masanori Shimomura,
  • Shunta Ishihara,
  • Tatsuo Furuya,
  • Kenji Kameyama,
  • Masayoshi Inoue

摘要

Purpose

To assess the usefulness of and predictive factors for pleurodesis using 50% glucose solution to treat air leak after pulmonary resection.

Methods

The subjects of this retrospective study were 70 patients from three Japanese institutions, who were treated with 50% glucose solution for postoperative air leak between April, 2015 and March, 2023. Air leak was monitored using a digital drainage system. We analyzed the patient characteristics, surgical details, and outcomes. Successful pleurodesis was defined as control of the air leak within two attempts and no recurrence within 1 month after drain removal. Predictors of success were identified using multivariable logistic regression.

Results

Pleurodesis with 50% glucose solution treated air leak successfully in 58 patients (83%), with a median time from resection to pleurodesis of 4 days. Air leak control was achieved within 2 days in 93% of these patients. Air leak volume < 300 mL/min before pleurodesis and an air space rate < 10% calculated on chest radiograph were independent predictors of success. The success rate for patients with both or none of these factors was 97% and 29%, respectively. No life-threatening complications were observed.

Conclusions

Pleurodesis using 50% glucose solution could be useful for managing postoperative air leak, especially in patients with an air leak volume < 300 mL/min and an air space rate < 10%.