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Purpose <p>Current diagnostic modalities for differentiating between benign and malignant cervical lymph nodes in patients with thyroid cancer are imprecise and time-consuming. The real-time intraoperative detection of malignancy in suspicious lesions could improve the medical management of these patients. This human study was undertaken to evaluate a precise, newly developed Electrical Lymph-Node Scanning (ELS) system to facilitate the effective treatment of cervical LNs in thyroid cancer patients.</p> Methods <p>Using the ELS, we examined a collective 109 radiologically suspicious lymph nodes from 36 patients after dissection and compared the ELS results with the histopathological findings.</p> Results <p>A total of 27 involved lymph nodes were correctly diagnosed, while 75 reactive or free lymph nodes were correctly identified as uninvolved lymph nodes by ELS (as 3 false negatives and 4 false positives) with total sensitivity and specificity of 90% and 94.9%, respectively. The corresponding negative and positive predictive values were 87.1% and 96.2%, respectively.</p> Conclusions <p>Results from this clinical study demonstrate the value of the ELS as a surgical assist adjunct for differentiating equivocal lesions during neck dissection surgery for patients with different types of thyroid cancer.</p>

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Impedance-based detection of cervical lymph-node involvement in thyroid cancer patients: a human model study

  • 期刊论文

  • 发表日期：

    2025年4月3日

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  • Hossein Ataee,
  • Mohammad Seraj,
  • Reihane Mahdavi,
  • Ali Fardoost,
  • Abdollah Shafiee,
  • Khosro Shamsi,
  • Mohammadreza Fattahi,
  • Hojat Ebrahiminik,
  • Parisa Hoseinpour,
  • Shahram Sane,
  • Mehran Ghazimoghaddam,
  • Mohammad Esmaeel Akbari,
  • Mohammad Abdolahad

摘要

Purpose

Current diagnostic modalities for differentiating between benign and malignant cervical lymph nodes in patients with thyroid cancer are imprecise and time-consuming. The real-time intraoperative detection of malignancy in suspicious lesions could improve the medical management of these patients. This human study was undertaken to evaluate a precise, newly developed Electrical Lymph-Node Scanning (ELS) system to facilitate the effective treatment of cervical LNs in thyroid cancer patients.

Methods

Using the ELS, we examined a collective 109 radiologically suspicious lymph nodes from 36 patients after dissection and compared the ELS results with the histopathological findings.

Results

A total of 27 involved lymph nodes were correctly diagnosed, while 75 reactive or free lymph nodes were correctly identified as uninvolved lymph nodes by ELS (as 3 false negatives and 4 false positives) with total sensitivity and specificity of 90% and 94.9%, respectively. The corresponding negative and positive predictive values were 87.1% and 96.2%, respectively.

Conclusions

Results from this clinical study demonstrate the value of the ELS as a surgical assist adjunct for differentiating equivocal lesions during neck dissection surgery for patients with different types of thyroid cancer.