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Purpose <p>To investigate the effect of preoperative prealbumin levels on long-term survival outcomes after gastrectomy in patients with gastric cancer (GC) dichotomized based on age.</p> Methods <p>This retrospective cohort study included consecutive patients who underwent radical gastrectomy for primary stage I–III GC between May 2006 and March 2017. Patients were allocated to groups based on age (≥ 70 or &lt; 70&#xa0;years) and subgroups based on prealbumin levels (high, ≥ 22&#xa0;mg/dL; moderate, 15–22&#xa0;mg/dL; or low, &lt; 15&#xa0;mg/dL), and multivariate Cox regression was used for survival analyses.</p> Results <p>Of 4732 patients, 3172 (67.0%) were aged &lt; 70&#xa0;years and 1560 (33.0%) were ≥ 70&#xa0;years of age. The median follow-up period was 66&#xa0;months. A low prealbumin level was an independent prognostic factor for poor overall survival in older patients only [hazard ratio, 2.057; 95% confidence interval, 1.528–2.770; <i>P</i> &lt; 0.001]. A low prealbumin level was an independent prognostic factor for poor other-cause survival in the older (hazard ratio: 2.719, 95% confidence interval: 1.887–3.918, <i>P</i> &lt; 0.001) and younger (HR: 4.611, 95% CI 2.424–8.772, <i>P</i> &lt; 0.001) groups.</p> Conclusion <p>Low preoperative prealbumin levels were associated with poor overall survival in older patients with GC after gastrectomy and with earlier non-GC death in older and younger patients.</p>

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Preoperative low prealbumin independently predicts non-gastric cancer death after gastrectomy in elderly and young patients: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2025年1月27日

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  • Ryota Matsui,
  • Souya Nunobe,
  • Motonari Ri,
  • Rie Makuuchi,
  • Tomoyuki Irino,
  • Masaru Hayami,
  • Manabu Ohashi,
  • Takeshi Sano

摘要

Purpose

To investigate the effect of preoperative prealbumin levels on long-term survival outcomes after gastrectomy in patients with gastric cancer (GC) dichotomized based on age.

Methods

This retrospective cohort study included consecutive patients who underwent radical gastrectomy for primary stage I–III GC between May 2006 and March 2017. Patients were allocated to groups based on age (≥ 70 or < 70 years) and subgroups based on prealbumin levels (high, ≥ 22 mg/dL; moderate, 15–22 mg/dL; or low, < 15 mg/dL), and multivariate Cox regression was used for survival analyses.

Results

Of 4732 patients, 3172 (67.0%) were aged < 70 years and 1560 (33.0%) were ≥ 70 years of age. The median follow-up period was 66 months. A low prealbumin level was an independent prognostic factor for poor overall survival in older patients only [hazard ratio, 2.057; 95% confidence interval, 1.528–2.770; P < 0.001]. A low prealbumin level was an independent prognostic factor for poor other-cause survival in the older (hazard ratio: 2.719, 95% confidence interval: 1.887–3.918, P < 0.001) and younger (HR: 4.611, 95% CI 2.424–8.772, P < 0.001) groups.

Conclusion

Low preoperative prealbumin levels were associated with poor overall survival in older patients with GC after gastrectomy and with earlier non-GC death in older and younger patients.