Differences in glycemic trends due to reconstruction methods after proximal gastrectomy from the perspective of continuous glucose-monitoring

期刊论文
发表日期：

2024年4月23日

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Katsutoshi Shoda,
Takeshi Kubota,
Yoshihiko Kawaguchi,
Hidenori Akaike,
Suguru Maruyama,
Yudai Higuchi,
Takashi Nakayama,
Ryo Saito,
Koichi Takiguchi,
Shinji Furuya,
Kensuke Shiraishi,
Hidetake Amemiya,
Hiromichi Kawaida,
Daisuke Ichikawa

摘要

Purpose

In recent years, clinicians have focused on the importance of preventing hypoglycemia. We evaluated the impact of different reconstruction procedures after proximal gastrectomy on glycemic variability in non-diabetic patients with gastric cancer.

Methods

This prospective observational study was conducted between April 2020 and March 2023. Flash continuous glucose-monitoring, a novel method for assessing glycemic control, was used to evaluate the glycemic profiles after gastrectomy. A flash continuous glucose-monitoring sensor was placed subcutaneously at the time of discharge, and glucose trends were evaluated for 2 weeks.

Results

The anastomotic methods for proximal gastrectomy were esophagogastrostomy in 10 patients and double-tract reconstruction in 10 patients. The time below this range (glucose levels < 70 mg/dL) was significantly higher in the double-tract reconstruction group than in the esophagogastrostomy group (p = 0.049). A higher nocturnal time below this range was significantly correlated with an older age and double-tract reconstruction (p = 0.025 and p = 0.025, respectively).

Conclusion

These findings provide new insights into reconstruction methods after proximal gastrectomy by assessing postoperative hypoglycemia in non-diabetic patients with gastric cancer.