Introduction <p>the use of Automated Insulin Delivery (AID) systems has increased in pregnant women with type 1 diabetes (DM1). To date, little data exist regarding glucose control and insulin modifications with AID in automode during delivery and in the postpartum period.</p> Methods <p>we retrospectively evaluated pregnancy-specific metrics and insulin variations in a short peripartum period in 14 DM1 users of the MiniMed™780G pump in closed loop mode from pregestational care to the postpartum period.</p> Results <p>glycemic control during labour and delivery was optimal, with Time In Range 63–140&#xa0;mg/dl (pTIR) did not significantly change, remaining nearly the same from 48&#xa0;h before to 48 after the time of birth (85%). Variations in the Total insulin daily dose (TDD) were mainly influenced by manual boluses rather than the autobasal insulin in all examined periods. Auto basal insulin + autocorrection boluses reduced by 17.5% immediately after delivery and by 31% in the early postpartum period (14 days).</p> Conclusions <p>this is the first study to report on insulin variations with an AID system in automode during the strict peripartum period, before and after the time of birth. pTIR did not significantly change, remaining nearly the same from 48&#xa0;h before to 48 after the time of birth, despite the dramatic variations in insulin requirements, with unexpected little variation in autobasal insulin. It is possible that, for patients with very good glycemic control using Minimed^TM780G, the manual basal rate needs to be reduced less than the usual 50% after delivery, if switching to manual mode for any reason. Further research is needed to develop a protocol for glucose management in women with AID systems during and after delivery.</p>