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Aims <p>Neonatal diabetes mellitus (NDM) occurs before 6–12 months of age and is commonly caused by activating mutations in <i>KCNJ11</i> (<i>KCNJ11</i>-NDM) or <i>ABCC8</i>. Because of brain expression of these mutant ATP-dependent potassium channels, a spectrum of divergent neurodevelopmental difficulties have been described, including developmental delay, epilepsy, and neonatal diabetes (DEND). However, information on anxiety, social responsiveness, and grit is limited.</p> Methods <p>Individuals with <i>KCNJ11</i>-NDM (<i>N</i> = 12) and their unaffected siblings (<i>N</i> = 12) were recruited through the University of Chicago Monogenic Diabetes Registry and participants or their parent/caregiver completedthe Screen for Adult/Child Anxiety Related Disorder (SCAARED/SCARED), the Social Responsiveness Scale, Second Edition (SRS-2), and the Grit Scale.</p> Results <p>Mean SRS-2 scores were significantly different between <i>KCNJ11</i>-NDM and sibling controls (<i>P</i> = &lt;0.001 ), with 7/10 affected participants, and 0 /11 siblings, having scores suggestive of autism spectrum disorder (ASD). Differences in anxiety (<i>P</i> = 0.69) and grit (<i>P</i> = 0.46) were not significant when compared to sibling controls; however, 58% (7/12) of <i>KCNJ11</i>-NDM participants and 40% (4/10) of sibling controls had scores indicating an anxiety disorder by either self- or parent-report.</p> Conclusions <p>Our results agree with previous studies suggesting significant difficulties with social functioning in <i>KCNJ11</i>-NDM, with 7/10 participants having scores suggestive of ASD, strongly reinforcing the need for early neurodevelopmental screening to allow for prompt support. Our report adds to the knowledge of this population in finding robust grit scores but with a high level of anxiety in both <i>KCNJ11-</i>NDM and unaffected siblings. Although families affected by <i>KCNJ11</i>-NDM may have a high risk of anxiety disorders, it is encouraging that affected and unaffected children exhibit robust self-resiliency that will help support functioning through the challenges of life. Study of additional individuals will help to clarify specific challenges, long-term outcomes, and best approaches for monitoring and support.</p>

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Anxiety, social responsiveness, and grit among patients with KCNJ11-related neonatal diabetes compared to unaffected siblings

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月27日

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  • Jui M. Desai,
  • Lisa R. Letourneau-Freiberg,
  • Kristen E. Wroblewski,
  • Megan N. Scott,
  • Michael E. Msall,
  • Siri Atma W. Greeley

摘要

Aims

Neonatal diabetes mellitus (NDM) occurs before 6–12 months of age and is commonly caused by activating mutations in KCNJ11 (KCNJ11-NDM) or ABCC8. Because of brain expression of these mutant ATP-dependent potassium channels, a spectrum of divergent neurodevelopmental difficulties have been described, including developmental delay, epilepsy, and neonatal diabetes (DEND). However, information on anxiety, social responsiveness, and grit is limited.

Methods

Individuals with KCNJ11-NDM (N = 12) and their unaffected siblings (N = 12) were recruited through the University of Chicago Monogenic Diabetes Registry and participants or their parent/caregiver completedthe Screen for Adult/Child Anxiety Related Disorder (SCAARED/SCARED), the Social Responsiveness Scale, Second Edition (SRS-2), and the Grit Scale.

Results

Mean SRS-2 scores were significantly different between KCNJ11-NDM and sibling controls (P = <0.001 ), with 7/10 affected participants, and 0 /11 siblings, having scores suggestive of autism spectrum disorder (ASD). Differences in anxiety (P = 0.69) and grit (P = 0.46) were not significant when compared to sibling controls; however, 58% (7/12) of KCNJ11-NDM participants and 40% (4/10) of sibling controls had scores indicating an anxiety disorder by either self- or parent-report.

Conclusions

Our results agree with previous studies suggesting significant difficulties with social functioning in KCNJ11-NDM, with 7/10 participants having scores suggestive of ASD, strongly reinforcing the need for early neurodevelopmental screening to allow for prompt support. Our report adds to the knowledge of this population in finding robust grit scores but with a high level of anxiety in both KCNJ11-NDM and unaffected siblings. Although families affected by KCNJ11-NDM may have a high risk of anxiety disorders, it is encouraging that affected and unaffected children exhibit robust self-resiliency that will help support functioning through the challenges of life. Study of additional individuals will help to clarify specific challenges, long-term outcomes, and best approaches for monitoring and support.