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Background <p> Nodular fasciitis (NF) is a benign pseudosarcomatous myofibroblastic lesion rarely occurring in the spinal canal. USP6 rearrangement is characteristic of NF, but intradural cervical NF after spine surgery with a novel <i>MIR22HG::USP6</i> fusion has not been documented.</p> Case description <p> A 70-year-old male presented with acute limb paralysis 2 months after uneventful anterior cervical discectomy and fusion. MRI revealed an intradural extramedullary mass at C6–C7 causing severe cord compression. The lesion was totally resected emergently. Histopathology, immunohistochemistry, and FISH verified NF with USP6 rearrangement. Next-generation sequencing detected a novel<i> MIR22HG</i> (exon 1)::<i>USP6</i> (intron 9) fusion. The patient fully recovered neurologically with no recurrence at 1-year follow-up.</p> Conclusions <p> This is the first reported case of postoperative intradural cervical NF harboring a novel <i>MIR22HG::USP6</i> fusion. It broadens the anatomical and molecular spectrum of NF. Early and complete surgical resection yields excellent long-term outcomes.</p>

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Nodular fasciitis of the intradural cervical spine with *MIR22HG::USP6* fusion a rare postoperative occurrence and novel molecular pathogenesis

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Dong Xie,
  • Hao Wu,
  • Mingliang Shi,
  • Yao Zhang,
  • Zusheng Zang,
  • Lili Yang

摘要

Background

Nodular fasciitis (NF) is a benign pseudosarcomatous myofibroblastic lesion rarely occurring in the spinal canal. USP6 rearrangement is characteristic of NF, but intradural cervical NF after spine surgery with a novel MIR22HG::USP6 fusion has not been documented.

Case description

A 70-year-old male presented with acute limb paralysis 2 months after uneventful anterior cervical discectomy and fusion. MRI revealed an intradural extramedullary mass at C6–C7 causing severe cord compression. The lesion was totally resected emergently. Histopathology, immunohistochemistry, and FISH verified NF with USP6 rearrangement. Next-generation sequencing detected a novel MIR22HG (exon 1)::USP6 (intron 9) fusion. The patient fully recovered neurologically with no recurrence at 1-year follow-up.

Conclusions

This is the first reported case of postoperative intradural cervical NF harboring a novel MIR22HG::USP6 fusion. It broadens the anatomical and molecular spectrum of NF. Early and complete surgical resection yields excellent long-term outcomes.