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Objective <p>To evaluate the accuracy of magnetic resonance (MR) spectroscopy in differentiating vertebral hemangiomas from spinal metastases.</p> Background <p>MR spectroscopy (MRS) quantifies lesion composition, particularly lipid and water content. This study investigates the use of MRS-derived lipid-to-water ratios (LWRs) to distinguish typical and atypical vertebral hemangiomas (VHs) from spinal metastases.</p> Methods <p>In this IRB-approved, HIPAA-compliant prospective study, 77 vertebral regions of interest were evaluated via MRS. Lesions included typical VHs, atypical VHs, metastases, and normal bone marrow. Lipid and water spectral peaks were analyzed to calculate LWRs. ANOVA with Bonferroni correction assessed statistical significance across lesion types.</p> Results <p>Mean (SD) LWRs were control 0.98 (0.59), typical VH 3.37 (2.31), atypical VH 1.34 (1.77), and metastases 1.22 (1.58). ANOVA confirmed a significant effect of lesion type on LWR (<i>p</i> &lt; .001). Pairwise comparisons showed significant differences between typical VH and all other groups, while atypical VH and metastases were not significantly different.</p> Conclusion <p>MRS effectively differentiates typical VH from metastases and atypical VH based on LWR. The modality shows promise as a non-invasive tool in lesion characterization.</p>

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MR spectroscopy in differentiating spinal atypical hemangioma from metastasis: preliminary results

  • 期刊论文

  • 发表日期：

    2026年2月10日

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  • Anousheh Sayah,
  • Ayat Sharif,
  • Clark Restrepo,
  • Erini Makariou

摘要

Objective

To evaluate the accuracy of magnetic resonance (MR) spectroscopy in differentiating vertebral hemangiomas from spinal metastases.

Background

MR spectroscopy (MRS) quantifies lesion composition, particularly lipid and water content. This study investigates the use of MRS-derived lipid-to-water ratios (LWRs) to distinguish typical and atypical vertebral hemangiomas (VHs) from spinal metastases.

Methods

In this IRB-approved, HIPAA-compliant prospective study, 77 vertebral regions of interest were evaluated via MRS. Lesions included typical VHs, atypical VHs, metastases, and normal bone marrow. Lipid and water spectral peaks were analyzed to calculate LWRs. ANOVA with Bonferroni correction assessed statistical significance across lesion types.

Results

Mean (SD) LWRs were control 0.98 (0.59), typical VH 3.37 (2.31), atypical VH 1.34 (1.77), and metastases 1.22 (1.58). ANOVA confirmed a significant effect of lesion type on LWR (p < .001). Pairwise comparisons showed significant differences between typical VH and all other groups, while atypical VH and metastases were not significantly different.

Conclusion

MRS effectively differentiates typical VH from metastases and atypical VH based on LWR. The modality shows promise as a non-invasive tool in lesion characterization.