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Purpose <p>This study aimed to test the hypothesis that a dose-response relationship exists between adherence to Enhanced Recovery After Surgery (ERAS) protocols and postoperative outcomes in geriatric patients undergoing separation surgery for spinal metastases.</p> Methods <p>In a single-center retrospective cohort study, 128 patients aged ≥ 70 years undergoing elective separation surgery for symptomatic spinal metastases (2020–2023) were included. Adherence to eight core ERAS components was assessed, and an overall adherence score was calculated. The primary outcome was composite complications (Clavien-Dindo Grade ≥ II) within 30 days. Multivariable logistic regression, adjusted for frailty and preoperative albumin, analyzed the association between adherence and outcomes.</p> Results <p>Median ERAS adherence was 75%. Each 10% increase in adherence was independently associated with 31% lower odds of major complications (aOR = 0.69; 95% CI: 0.55–0.88; <i>p</i> = 0.002). The High-Adherence group (≥ 75% adherence) experienced significantly shorter length of stay (5 vs. 7 days, <i>p</i> &lt; 0.001) and better pain control at discharge (median VAS 2 vs. 3, <i>p</i> &lt; 0.001) compared to the Low-Adherence group.</p> Conclusion <p>Our analysis suggests a significant dose-response relationship between ERAS adherence and improved outcomes in geriatric spine metastasis surgery. Higher adherence was independently associated with lower odds of major complications and shorter recovery time, thereby supporting the concept of a “Precision ERAS” approach.</p>

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Dose-response relationship between enhanced recovery protocol adherence and outcomes in geriatric spine metastasis surgery

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Jian Zhou,
  • An’nan Hu,
  • Xilei Li,
  • Xiaogang Zhou,
  • Jian Dong

摘要

Purpose

This study aimed to test the hypothesis that a dose-response relationship exists between adherence to Enhanced Recovery After Surgery (ERAS) protocols and postoperative outcomes in geriatric patients undergoing separation surgery for spinal metastases.

Methods

In a single-center retrospective cohort study, 128 patients aged ≥ 70 years undergoing elective separation surgery for symptomatic spinal metastases (2020–2023) were included. Adherence to eight core ERAS components was assessed, and an overall adherence score was calculated. The primary outcome was composite complications (Clavien-Dindo Grade ≥ II) within 30 days. Multivariable logistic regression, adjusted for frailty and preoperative albumin, analyzed the association between adherence and outcomes.

Results

Median ERAS adherence was 75%. Each 10% increase in adherence was independently associated with 31% lower odds of major complications (aOR = 0.69; 95% CI: 0.55–0.88; p = 0.002). The High-Adherence group (≥ 75% adherence) experienced significantly shorter length of stay (5 vs. 7 days, p < 0.001) and better pain control at discharge (median VAS 2 vs. 3, p < 0.001) compared to the Low-Adherence group.

Conclusion

Our analysis suggests a significant dose-response relationship between ERAS adherence and improved outcomes in geriatric spine metastasis surgery. Higher adherence was independently associated with lower odds of major complications and shorter recovery time, thereby supporting the concept of a “Precision ERAS” approach.