Scholarlink

Introduction <p>Intramedullary melanocytomas are rare central nervous system tumors originating from melanocytes within the spinal cord. This systematic review aims to synthesize the clinical, imaging, histopathological, and therapeutic characteristics of intramedullary melanocytoma. We also present a case of thoracic spinal melanocytoma, emphasizing clinical, radiological, immunohistopathological, and management findings of this tumor.</p> Method <p>We conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including studies published in the SCOPUS, MEDLINE, and Google Scholar databases from January 2005 to July 2025.</p> Result <p>The initial search identified 97 articles. Following the removal of duplicates and non-relevant entries, 23 manuscripts were included in the review. There were 26 patients, comprising 12 males and 14 females. The mean age was 43.16 ± 18.92 years. Melanocytoma was in the thoracic spine in 19 cases. Tumor resection was performed in all cases. Radiotherapy was indicated in 5 cases. Recurrence was noted in 5 cases. We reported a case of a 29-year-old woman who presented with progressive thoracic back pain, spastic paraparesis, and urinary dysfunction. MRI revealed an intramedullary mass at the T9–T10 level, which was mildly hyperintense on T1-weighted sequences with intense and homogeneous contrast enhancement. Gross total resection was achieved. Histopathological and immunohistochemical analyses confirmed the diagnosis of melanocytoma.</p> Conclusion <p>The diagnosis of spinal melanocytomas can be challenging due to their rarity and overlapping clinical and radiological features with other intramedullary neoplasms. Surgical resection remains the cornerstone of therapeutic management. However, postoperative neurological deficits are frequently observed.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Intramedullary melanocytoma: a systematic review

  • 期刊论文

  • 发表日期：

    2025年12月10日

查看全文
  • Maroua Slouma,
  • Hanen Besrour,
  • Firas Akrout,
  • Samar Zarati,
  • Karima Tlili,
  • Ines Aloulou,
  • Sameh Achoura

摘要

Introduction

Intramedullary melanocytomas are rare central nervous system tumors originating from melanocytes within the spinal cord. This systematic review aims to synthesize the clinical, imaging, histopathological, and therapeutic characteristics of intramedullary melanocytoma. We also present a case of thoracic spinal melanocytoma, emphasizing clinical, radiological, immunohistopathological, and management findings of this tumor.

Method

We conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, including studies published in the SCOPUS, MEDLINE, and Google Scholar databases from January 2005 to July 2025.

Result

The initial search identified 97 articles. Following the removal of duplicates and non-relevant entries, 23 manuscripts were included in the review. There were 26 patients, comprising 12 males and 14 females. The mean age was 43.16 ± 18.92 years. Melanocytoma was in the thoracic spine in 19 cases. Tumor resection was performed in all cases. Radiotherapy was indicated in 5 cases. Recurrence was noted in 5 cases. We reported a case of a 29-year-old woman who presented with progressive thoracic back pain, spastic paraparesis, and urinary dysfunction. MRI revealed an intramedullary mass at the T9–T10 level, which was mildly hyperintense on T1-weighted sequences with intense and homogeneous contrast enhancement. Gross total resection was achieved. Histopathological and immunohistochemical analyses confirmed the diagnosis of melanocytoma.

Conclusion

The diagnosis of spinal melanocytomas can be challenging due to their rarity and overlapping clinical and radiological features with other intramedullary neoplasms. Surgical resection remains the cornerstone of therapeutic management. However, postoperative neurological deficits are frequently observed.