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<p>The incidence of vertebral osteomyelitis is increasing with heterogeneity in clinical presentation and outcome. Lack of pathogen identification could complicate clinical management. This study aimed to compare the clinical characteristics, management and outcome of patients with vertebral osteomyelitis (VOs) with known aetiology (KAe) and unknown aetiology (UAe). A total of 92 patients with VOs were included, 57 (62%) with KAe and 35 (38%) with UAe. In our cohort, VO with known etiology was more commonly related to a worse clinical presentation, more frequent hospitalization, required more therapeutic lines, and experienced delays in switching to oral therapy.</p>

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Clinical characteristics, management, and outcome of vertebral osteomyelitis with known versus unknown aetiology: a single-centre retrospective study between 2017-2023

  • 期刊论文

  • 发表日期：

    2025年11月3日

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  • Chiara Maci,
  • Roberta Monardo,
  • Sara Diotallevi,
  • Riccardo Lolatto,
  • Elena Busnardo,
  • Enzo Scifo,
  • Francesco Scomazzoni,
  • Carlo Mandelli,
  • Marco Ripa,
  • Antonella Castagna,
  • Chiara Tassan Din

摘要

The incidence of vertebral osteomyelitis is increasing with heterogeneity in clinical presentation and outcome. Lack of pathogen identification could complicate clinical management. This study aimed to compare the clinical characteristics, management and outcome of patients with vertebral osteomyelitis (VOs) with known aetiology (KAe) and unknown aetiology (UAe). A total of 92 patients with VOs were included, 57 (62%) with KAe and 35 (38%) with UAe. In our cohort, VO with known etiology was more commonly related to a worse clinical presentation, more frequent hospitalization, required more therapeutic lines, and experienced delays in switching to oral therapy.