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Purpose <p>To propose and elucidate a novel MRI imaging feature, termed “Greta oto” sign, which is a specific sign for detecting axial myopathy patients with low back pain as the major clinical manifestation.</p> Methods <p>From 2020 to 2024, four patients with axial myopathy with low back pain as the main clinical manifestation were retrospectively studied. The MRI findings and clinical features were analyzed.</p> Results <p>There were three females and one male, aged from 38 to 55 years. MRI examinations showed significant atrophy and fat infiltration of the bilateral erector spinae muscles, as well as varying degrees of atrophy observed in the multifidus muscles. The fatty degeneration in the erector spinae and multifidus muscles, together with the vertebral bodies and spinous processes, produced a distinctive imaging manifestation resembling a “Greta oto” sign on axial T2-weighted MRI scans in all patients. Ultimately, all four patients were referred to the neurology department, where the diagnosis of myopathy was confirmed by muscle biopsy (one myopathy with early-onset Paget disease and frontotemporal dementia type 1 (IBMPFD), one HMGCR antibody-positive myopathy, one myotonic dystrophy and one limb-girdle muscular dystrophy.</p> Conclusions <p>The “Greta Otto” sign may be a specific MRI manifestation of axial myopathy with low back pain as the primary clinical manifestation. This sign may help clinicians identify axial myopathy and reduce the likelihood of misdiagnosis as nonspecific low back pain.</p>

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The “greta oto” sign for diagnosing axial myopathy with low back pain as the major clinical manifestation: a novel MRI sign with report of four cases

  • 期刊论文

  • 发表日期：

    2025年8月9日

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  • Jingming Wang,
  • Lei Wang,
  • Hongwei Guo,
  • Weimin Huang

摘要

Purpose

To propose and elucidate a novel MRI imaging feature, termed “Greta oto” sign, which is a specific sign for detecting axial myopathy patients with low back pain as the major clinical manifestation.

Methods

From 2020 to 2024, four patients with axial myopathy with low back pain as the main clinical manifestation were retrospectively studied. The MRI findings and clinical features were analyzed.

Results

There were three females and one male, aged from 38 to 55 years. MRI examinations showed significant atrophy and fat infiltration of the bilateral erector spinae muscles, as well as varying degrees of atrophy observed in the multifidus muscles. The fatty degeneration in the erector spinae and multifidus muscles, together with the vertebral bodies and spinous processes, produced a distinctive imaging manifestation resembling a “Greta oto” sign on axial T2-weighted MRI scans in all patients. Ultimately, all four patients were referred to the neurology department, where the diagnosis of myopathy was confirmed by muscle biopsy (one myopathy with early-onset Paget disease and frontotemporal dementia type 1 (IBMPFD), one HMGCR antibody-positive myopathy, one myotonic dystrophy and one limb-girdle muscular dystrophy.

Conclusions

The “Greta Otto” sign may be a specific MRI manifestation of axial myopathy with low back pain as the primary clinical manifestation. This sign may help clinicians identify axial myopathy and reduce the likelihood of misdiagnosis as nonspecific low back pain.