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Objective <p>To investigate the association between paravertebral muscle quality and Modic changes (MCs) in patients with chronic nonspecific low back pain (CNLBP).</p> Methods <p>The cases and imaging data of patients with CLBP who were treated in our hospital from December 2020 to December 2023 were retrospectively collected. Patients were categorized into MCs group and non-MCs group according to the presence or absence of Modic changes in lumbar spine MRI. Based on lumbar MRI, the cross-sectional areas (CSA) of bilateral multifidus, erector spinae and psoas major muscles, fat infiltration rate (FIR) and lumbar indentation value (LIV) were measured in the L2-S1 segments of both groups of patients, respectively.</p> Results <p>The VAS score of patients in the MCs group was significantly higher than that of patients in non-MCs group, and the degree of intervertebral disc degeneration was more severe than that of patients in non-MCs group (<i>P</i> &lt; 0.05). At the L2-L3 and L3-L4 segments, the CSA of the bilateral erector spinae muscles in the MCs group was significantly smaller than that of patients in non-MCs group (<i>P</i> &lt; 0.05). On the contrary, the FIR of paravertebral muscle was higher than that of patients in non-MCs group (<i>P</i> &lt; 0.05). At the L4-L5 and L5-S1 segments, the CSA of bilateral erector spinae and multifus muscles in the MCs group were smaller than those in the non-MCs group, and the FIR was higher than that in the non-MCs group (<i>P</i> &lt; 0.05). The LIV of the L4-L5 and L5-S1 segments in the MCs group were significantly lower than those in the non-MCs group (<i>P</i> &lt; 0.05). Binary logistic regression analysis showed that there might be a association between low bilateral multifidus, erector spinae CSA and LIV, and high multifidus, erector spinae FIR and Modic changes.</p> Conclusion <p>Our research results indicate that there is a association between paravertebral muscle quality and Modic changes in patients with CNLBP. There may be an interaction between low bilateral multifidus, erector spinae CSA and LIV, high bilateral multifidus, erector spinae FIR and lumbar Modic changes.</p>

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A cross-sectional association study of paravertebral muscle quality and modic changes in patients with chronic nonspecific low back pain

  • 期刊论文

  • 发表日期：

    2025年6月18日

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  • Ningning Feng,
  • Shuyin Tan,
  • Sixue Chen,
  • Ziye Qiu,
  • Wenhao Li,
  • Guozheng Jiang,
  • Junji Yang,
  • Xing Yu,
  • Dingyan Zhao

摘要

Objective

To investigate the association between paravertebral muscle quality and Modic changes (MCs) in patients with chronic nonspecific low back pain (CNLBP).

Methods

The cases and imaging data of patients with CLBP who were treated in our hospital from December 2020 to December 2023 were retrospectively collected. Patients were categorized into MCs group and non-MCs group according to the presence or absence of Modic changes in lumbar spine MRI. Based on lumbar MRI, the cross-sectional areas (CSA) of bilateral multifidus, erector spinae and psoas major muscles, fat infiltration rate (FIR) and lumbar indentation value (LIV) were measured in the L2-S1 segments of both groups of patients, respectively.

Results

The VAS score of patients in the MCs group was significantly higher than that of patients in non-MCs group, and the degree of intervertebral disc degeneration was more severe than that of patients in non-MCs group (P < 0.05). At the L2-L3 and L3-L4 segments, the CSA of the bilateral erector spinae muscles in the MCs group was significantly smaller than that of patients in non-MCs group (P < 0.05). On the contrary, the FIR of paravertebral muscle was higher than that of patients in non-MCs group (P < 0.05). At the L4-L5 and L5-S1 segments, the CSA of bilateral erector spinae and multifus muscles in the MCs group were smaller than those in the non-MCs group, and the FIR was higher than that in the non-MCs group (P < 0.05). The LIV of the L4-L5 and L5-S1 segments in the MCs group were significantly lower than those in the non-MCs group (P < 0.05). Binary logistic regression analysis showed that there might be a association between low bilateral multifidus, erector spinae CSA and LIV, and high multifidus, erector spinae FIR and Modic changes.

Conclusion

Our research results indicate that there is a association between paravertebral muscle quality and Modic changes in patients with CNLBP. There may be an interaction between low bilateral multifidus, erector spinae CSA and LIV, high bilateral multifidus, erector spinae FIR and lumbar Modic changes.