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<p><i>Carpobrotus edulis </i>(L.)<i> N. E. Br., var. rubescens Druce,</i> belongs to the Aizoaceae family and is a succulent plant with many potential medicinal and nutritional properties. This study aimed to evaluate the acute oral toxicity and anti-inflammatory activity of its ethanolic extract obtained by ultrasound-assisted extraction (UAE) in Wistar rats. The ethanolic extract was prepared by UAE, concentrated under reduced pressure, and administered to adult albino Wistar rats (3 months old, 200 ± 20 g). Acute toxicity was assessed at 2000 mg/kg following OECD guideline 423. Anti-inflammatory activity was evaluated using carrageenan-induced paw oedema at doses of 200 and 400 mg/kg, with Diclofenac 10 mg/kg as a positive control. Serum AST, ALT, urea, and creatinine were measured. Histological analyses of liver, kidneys, and paws were performed after haematoxylin and eosin staining. No mortality or clinical signs of toxicity were observed at 2000 mg/kg, and biochemical parameters remained within normal ranges, indicating no hepatotoxicity or nephrotoxicity. In the paw oedema model, the 400 mg/kg extract reduced oedema by 72.04%, comparable to Diclofenac (72.73%), while the 200 mg/kg dose produced a moderate effect (56.13%). Histology confirmed preserved tissue architecture in liver, and reduced inflammatory infiltration and oedema in paw tissues at the higher dose.<i> C. edulis</i> ethanolic extract is safe at high oral doses and possesses significant anti-inflammatory activity, particularly at 400 mg/kg, supporting its potential as a natural therapeutic agent for inflammatory conditions.</p>

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Acute oral toxicity and anti-inflammatory activity of the ethanolic extract from Carpobrotus edulis (L.) N. E. Br., var. rubescens Druce in Wistar rats

  • 期刊论文

  • 发表日期：

    2026年7月3日

查看全文
  • Khatima Mezhoud,
  • El Amine Cheroual,
  • Chawki Bensouici,
  • Mohamed Zaouani,
  • Lynda Ainouz,
  • Ines Mezhoud,
  • Dalila Smati

摘要

Carpobrotus edulis (L.) N. E. Br., var. rubescens Druce, belongs to the Aizoaceae family and is a succulent plant with many potential medicinal and nutritional properties. This study aimed to evaluate the acute oral toxicity and anti-inflammatory activity of its ethanolic extract obtained by ultrasound-assisted extraction (UAE) in Wistar rats. The ethanolic extract was prepared by UAE, concentrated under reduced pressure, and administered to adult albino Wistar rats (3 months old, 200 ± 20 g). Acute toxicity was assessed at 2000 mg/kg following OECD guideline 423. Anti-inflammatory activity was evaluated using carrageenan-induced paw oedema at doses of 200 and 400 mg/kg, with Diclofenac 10 mg/kg as a positive control. Serum AST, ALT, urea, and creatinine were measured. Histological analyses of liver, kidneys, and paws were performed after haematoxylin and eosin staining. No mortality or clinical signs of toxicity were observed at 2000 mg/kg, and biochemical parameters remained within normal ranges, indicating no hepatotoxicity or nephrotoxicity. In the paw oedema model, the 400 mg/kg extract reduced oedema by 72.04%, comparable to Diclofenac (72.73%), while the 200 mg/kg dose produced a moderate effect (56.13%). Histology confirmed preserved tissue architecture in liver, and reduced inflammatory infiltration and oedema in paw tissues at the higher dose. C. edulis ethanolic extract is safe at high oral doses and possesses significant anti-inflammatory activity, particularly at 400 mg/kg, supporting its potential as a natural therapeutic agent for inflammatory conditions.