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<p>Cystic endometrial hyperplasia (CEH) is a progressive, pathologic remodeling of the endometrium, characterized by marked proliferation and cystic transformation of the endometrial glands. The pathogenesis is primarily attributable to hyperestrogenism. In small ruminants, the condition is commonly associated with the ingestion of phytoestrogen-rich forages. CEH represents a primary cause of permanent infertility. This report describes a specific occurrence of CEH in a domestic ewe, Torki Qashqai breed, 4-year-old, and 53 kg weight. Gross examination revealed multiple translucent cysts (3–8 mm) predominantly localized on the caruncles. Histopathological analysis confirmed glandular epithelial hyperplasia, cystic dilation of adnexal structures, and peri-glandular fibrosis.</p>

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Pathomorphological characterization of cystic endometrial hyperplasia in a sheep

  • 期刊论文

  • 发表日期：

    2026年5月18日

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  • Samin Khodaverdian,
  • Asghar Mogheiseh,
  • Nasrollah Ahmadi,
  • Mehdi Azari

摘要

Cystic endometrial hyperplasia (CEH) is a progressive, pathologic remodeling of the endometrium, characterized by marked proliferation and cystic transformation of the endometrial glands. The pathogenesis is primarily attributable to hyperestrogenism. In small ruminants, the condition is commonly associated with the ingestion of phytoestrogen-rich forages. CEH represents a primary cause of permanent infertility. This report describes a specific occurrence of CEH in a domestic ewe, Torki Qashqai breed, 4-year-old, and 53 kg weight. Gross examination revealed multiple translucent cysts (3–8 mm) predominantly localized on the caruncles. Histopathological analysis confirmed glandular epithelial hyperplasia, cystic dilation of adnexal structures, and peri-glandular fibrosis.