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<p>The investigation of potential biomarkers of depression may significantly advance diagnosis, prognosis and the development of effective drugs for its clinical management. This study aimed to determine the effects of quercetin on some haematological and brain lipid parameters in reserpine-induced depressive-like mice. Thirty-five mice served as subjects: Control group mice (group I, <i>n</i> = 5) were treated by oral gavage with normal saline (0.9%W/V). The remaining 30 mice were injected with reserpine 0.2&#xa0;mg/kg/day intraperitoneally for 15&#xa0;days to induce depressive-like symptoms, and randomly divided into 6 groups (groups II—VII, <i>n</i> = 5). They were treated every two successive days with intraperitoneal injection of 0.2&#xa0;mg/kg reserpine and once daily with 20&#xa0;mg/kg fluoxetine, graded doses of quercetin (20&#xa0;mg/kg, 40&#xa0;mg/kg, 80&#xa0;mg/kg), and 20&#xa0;mg/kg fluoxetine + 20&#xa0;mg/kg quercetin. The treatment regimen lasted 26&#xa0;days. The high-density lipoprotein concentration was significantly (<i>P</i> &lt; 0.05) higher in the 80&#xa0;mg/kg quercetin-treated group compared to the reserpinized mice alone. There was a significant (<i>P</i> &lt; 0.05) increase in RBC, Hb concentration, and packed cell volume in experimental mice compared to the depressive-like group alone. Significantly (<i>P</i> &lt; 0.05) higher platelet count was recorded with 40&#xa0;mg/kg quercetin-treated group, than in the depressive-like group alone. The results of systemic inflammatory immune index, revealed significant (<i>P</i> &lt; 0.05) decrease in 80&#xa0;mg/kg quercetin-treated group compared to the reserpinized group alone. In conclusion, these parameters suggest that they may serve as potential peripheral biomarkers, beneficial in elucidating the pathophysiologic mechanism and management of depression.</p>

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The effects of quercetin on haematological and brain lipid parameters of reserpine-induced depressive-like mice

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Samuel M. Okey,
  • Joseph O. Ayo,
  • Ahmed S. Isa,
  • Fatima A. Dawud

摘要

The investigation of potential biomarkers of depression may significantly advance diagnosis, prognosis and the development of effective drugs for its clinical management. This study aimed to determine the effects of quercetin on some haematological and brain lipid parameters in reserpine-induced depressive-like mice. Thirty-five mice served as subjects: Control group mice (group I, n = 5) were treated by oral gavage with normal saline (0.9%W/V). The remaining 30 mice were injected with reserpine 0.2 mg/kg/day intraperitoneally for 15 days to induce depressive-like symptoms, and randomly divided into 6 groups (groups II—VII, n = 5). They were treated every two successive days with intraperitoneal injection of 0.2 mg/kg reserpine and once daily with 20 mg/kg fluoxetine, graded doses of quercetin (20 mg/kg, 40 mg/kg, 80 mg/kg), and 20 mg/kg fluoxetine + 20 mg/kg quercetin. The treatment regimen lasted 26 days. The high-density lipoprotein concentration was significantly (P < 0.05) higher in the 80 mg/kg quercetin-treated group compared to the reserpinized mice alone. There was a significant (P < 0.05) increase in RBC, Hb concentration, and packed cell volume in experimental mice compared to the depressive-like group alone. Significantly (P < 0.05) higher platelet count was recorded with 40 mg/kg quercetin-treated group, than in the depressive-like group alone. The results of systemic inflammatory immune index, revealed significant (P < 0.05) decrease in 80 mg/kg quercetin-treated group compared to the reserpinized group alone. In conclusion, these parameters suggest that they may serve as potential peripheral biomarkers, beneficial in elucidating the pathophysiologic mechanism and management of depression.