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<p>Diabetes substantially impacts global human mortality and morbidity. The use of herbs for diabetes treatment is gaining global recognition due to its availability and affordability. This research examined the reno-protective properties of polyphenolic-rich extracts derived from <i>Vernonia amygdalina</i> leaves in streptozotocin-induced type-1 diabetic rats. This research utilized fifty-four rats, which were into nine groups of six: control, diabetic control (DM 50&#xa0;mg/kg), diabetic rats + 50&#xa0;mg/kg <i>V. amygdalina</i> crude extract (DM + CE), 50&#xa0;mg/kg free phenol fraction (DM + FP), 50&#xa0;mg/kg bound phenol fraction (DM + BP), 200&#xa0;mg/kg metformin (DM + MET), and corresponding groups of normal rats treated with each extract (CE, FP, and BP alone). The crude extract and polyphenolic-rich extracts were prepared following established protocols. Following the treatment period, the impact of the extract and its fractions on blood glucose levels, kidney function indicators, oxidative stress and antioxidant status, as well as inflammatory markers, were assessed. The crude extract and phenol fractions from <i>V. amygdalina</i> markedly decreased blood glucose levels (p &lt; 0.001). The onset of diabetes led to a marked elevation in urea, uric acid, malondialdehyde, and protein carbonyl levels, which were notably reversed by all the extracts. An observable elevation in TNF-α and IL-1β, coupled with a depletion in antioxidant enzymes, was noted in untreated diabetic rats. The administration of the extracts enhanced antioxidant enzyme activity and significantly elevated the concentration of the anti-inflammatory cytokine. The extracts improved the disruption of kidney histological architecture. The polyphenolic-rich fractions from <i>V. amygdalina</i> extracts protect renal tissue from hyperglycemia and oxidative stress, while also modulating inflammatory markers in streptozotocin-induced diabetes.</p>

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Reno-protective effect of polyphenolic-rich extracts from Vernonia amygdalina leaves in streptozotocin-induced type 1 diabetic rats

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Olawale Razaq Ajuwon,
  • Akinwunmi Oluwaseun Adeoye,
  • Damilola Rebecca Oladejo,
  • John Adeolu Falode,
  • Jude Akinyelu,
  • Basiru Olaitan Ajiboye

摘要

Diabetes substantially impacts global human mortality and morbidity. The use of herbs for diabetes treatment is gaining global recognition due to its availability and affordability. This research examined the reno-protective properties of polyphenolic-rich extracts derived from Vernonia amygdalina leaves in streptozotocin-induced type-1 diabetic rats. This research utilized fifty-four rats, which were into nine groups of six: control, diabetic control (DM 50 mg/kg), diabetic rats + 50 mg/kg V. amygdalina crude extract (DM + CE), 50 mg/kg free phenol fraction (DM + FP), 50 mg/kg bound phenol fraction (DM + BP), 200 mg/kg metformin (DM + MET), and corresponding groups of normal rats treated with each extract (CE, FP, and BP alone). The crude extract and polyphenolic-rich extracts were prepared following established protocols. Following the treatment period, the impact of the extract and its fractions on blood glucose levels, kidney function indicators, oxidative stress and antioxidant status, as well as inflammatory markers, were assessed. The crude extract and phenol fractions from V. amygdalina markedly decreased blood glucose levels (p < 0.001). The onset of diabetes led to a marked elevation in urea, uric acid, malondialdehyde, and protein carbonyl levels, which were notably reversed by all the extracts. An observable elevation in TNF-α and IL-1β, coupled with a depletion in antioxidant enzymes, was noted in untreated diabetic rats. The administration of the extracts enhanced antioxidant enzyme activity and significantly elevated the concentration of the anti-inflammatory cytokine. The extracts improved the disruption of kidney histological architecture. The polyphenolic-rich fractions from V. amygdalina extracts protect renal tissue from hyperglycemia and oxidative stress, while also modulating inflammatory markers in streptozotocin-induced diabetes.