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<p>The present research evaluates in vivo antihyperglycemic together with antioxidant vigor of wheatgrass on streptozotocin-induced hyperglycemic rats. The previous research on in vitro activity of wheatgrass documented its immense potentiality so the current research was inspired to explore its in vivo efficacy. Subsequently, the experimental rats were arbitrarily segregated comprising of four groups of three animals each. A single intraperitoneal injection of streptozotocin was administered to the rats to induce hyperglycemia. Freshly prepared 0.1&#xa0;M ice-cold citrate buffer was used at a dosage of 55&#xa0;mg/kg body mass. However, administering wheatgrass extract to hyperglycemic rats caused a drop in glycemia which indicates antidiabetic potentials of wheatgrass. Evaluation of antioxidant activity in all the rat groups by DPPH and FRAP assay revealed that wheatgrass extract improved the antioxidant activities in hyperglycemic rats, but the antioxidant activities considerably declined in streptozotocin-treated rats versus normal control rats. Further, administration of STZ significantly reduced GSH levels in hyperglycemic rats in comparison with control rats but subsequently the supplementation with wheatgrass extract considerably elevated GSH content in hyperglycemic rats. Moreover, MDA content considerably declined in hyperglycemic rats when treated with wheatgrass extract in contrast to hyperglycemic control rats. The supplementation of wheatgrass extract in hyperglycemic rats restored MDA content near to normal control rats. A considerable elevation in sialic acid of plasma was recorded in STZ-induced hyperglycemic rats versus control. However, supplementing extract of wheatgrass to diabetic rats restored the content of sialic acid. Subsequently, administration of wheatgrass extract to hyperglycemic rats showed a considerable decline in lipid profile, viz., total cholesterol, triglycerides, LDL, and VLDL levels, and a rise in HDL level. Furthermore, wheatgrass extract supplementation to hyperglycemic rats documented a significant decline in liver function parameters such as SGOT, SGPT, and alkaline phosphatase levels, as well as kidney function parameters such as urea and creatinine levels. Finally, the HPLC of wheatgrass extract revealed the presence of chlorophyllin and rutin conferring antidiabetic and antioxidant efficacy.</p>

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Assessment of antihyperglycemic and antioxidant vigor of wheatgrass in streptozotocin-induced hyperglycemic rats

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Renu Tripathi,
  • Neetu Mishra,
  • Dhananjay Pandey,
  • Kamal Shah,
  • Nagendra Singh Chauhan

摘要

The present research evaluates in vivo antihyperglycemic together with antioxidant vigor of wheatgrass on streptozotocin-induced hyperglycemic rats. The previous research on in vitro activity of wheatgrass documented its immense potentiality so the current research was inspired to explore its in vivo efficacy. Subsequently, the experimental rats were arbitrarily segregated comprising of four groups of three animals each. A single intraperitoneal injection of streptozotocin was administered to the rats to induce hyperglycemia. Freshly prepared 0.1 M ice-cold citrate buffer was used at a dosage of 55 mg/kg body mass. However, administering wheatgrass extract to hyperglycemic rats caused a drop in glycemia which indicates antidiabetic potentials of wheatgrass. Evaluation of antioxidant activity in all the rat groups by DPPH and FRAP assay revealed that wheatgrass extract improved the antioxidant activities in hyperglycemic rats, but the antioxidant activities considerably declined in streptozotocin-treated rats versus normal control rats. Further, administration of STZ significantly reduced GSH levels in hyperglycemic rats in comparison with control rats but subsequently the supplementation with wheatgrass extract considerably elevated GSH content in hyperglycemic rats. Moreover, MDA content considerably declined in hyperglycemic rats when treated with wheatgrass extract in contrast to hyperglycemic control rats. The supplementation of wheatgrass extract in hyperglycemic rats restored MDA content near to normal control rats. A considerable elevation in sialic acid of plasma was recorded in STZ-induced hyperglycemic rats versus control. However, supplementing extract of wheatgrass to diabetic rats restored the content of sialic acid. Subsequently, administration of wheatgrass extract to hyperglycemic rats showed a considerable decline in lipid profile, viz., total cholesterol, triglycerides, LDL, and VLDL levels, and a rise in HDL level. Furthermore, wheatgrass extract supplementation to hyperglycemic rats documented a significant decline in liver function parameters such as SGOT, SGPT, and alkaline phosphatase levels, as well as kidney function parameters such as urea and creatinine levels. Finally, the HPLC of wheatgrass extract revealed the presence of chlorophyllin and rutin conferring antidiabetic and antioxidant efficacy.