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<p>The distinction between iron deficiency anemia (IDA) and β-thalassemia trait (BTT) remains one of the most frequent diagnostic challenges in pediatric hematology. Recent findings by Shaat et al. highlight the variable performance of complete blood count (CBC)-derived indices under real-world clinical conditions. This commentary discusses the translational implications of these findings and proposes a decision-grade diagnostic framework integrating CBC indices, iron-related biomarkers, and confirmatory testing to enhance diagnostic accuracy, interpretability, and equity across diverse healthcare settings. </p>

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From static indices to decision-grade triage in pediatric microcytosis: a translational perspective on CBC-based differentiation of iron deficiency anemia and β-thalassemia trait

  • 期刊论文

  • 发表日期：

    2026年4月20日

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  • M. Srikanth,
  • Devadass Jayarajan

摘要

The distinction between iron deficiency anemia (IDA) and β-thalassemia trait (BTT) remains one of the most frequent diagnostic challenges in pediatric hematology. Recent findings by Shaat et al. highlight the variable performance of complete blood count (CBC)-derived indices under real-world clinical conditions. This commentary discusses the translational implications of these findings and proposes a decision-grade diagnostic framework integrating CBC indices, iron-related biomarkers, and confirmatory testing to enhance diagnostic accuracy, interpretability, and equity across diverse healthcare settings.