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<p>Cisplatin (CISP) is a platinum-based xenobiotic used for treating various types of solid cancers. Like other anticancer drugs, CISP presents toxic side effects, which makes its chemotherapeutic use a futile effort. As part of this present study, the preliminary in silico molecular docking study carried out on syringic acid (SAC) revealed a close binding affinity of -4.5&#xa0;kcal/mol compared with a known/documented activator recording a binding affinity of -4.6&#xa0;kcal/mol. In the in vivo experiment, we therefore investigated the therapeutic and protective effects of SAC in CISP-induced testicular toxicity in rats, as a way of mitigating the latter’s side effect. The experimental setup involved 5 groups of 7 rats each: control, CISP (5&#xa0;mg/kg) only, SAC (50&#xa0;mg/kg) pre- and post-treatments, and SAC (50&#xa0;mg/kg) only. Compared with the control group, CISP-induced gonadotoxicity was recorded, marked by a significant decrease in the serum levels of FSH, LH, testosterone, testis PI3K, NF-κB, and testis activities of GST and CAT. Also, a significant increase compared with the control in the levels of testis MDA, H<sub>2</sub>O<sub>2</sub>, GSH, testis protein expressions of p53 and caspase-3, and activities of testis GPx and SOD were seen. SAC treatments, especially the post-treatment, significantly ameliorated the effects of CISP-induced gonadotoxicity. Consequent upon the findings above, we concluded that the CISP-induced gonadotoxicity was tackled by SAC through its antioxidant property that counteracted the free radical production, lipid peroxidation, oxidative stress, and testicular apoptosis in rats.</p>

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Syringic acid assuages cisplatin-induced testicular apoptosis via p53 and caspase-3 inhibition and oxidative stress via the regulation of superoxide dismutase in male Wistar rats: in vivo and computational evidence

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Oluwatobi T. Somade,
  • Joy P. Anamelechi,
  • Teniola Ariyibi,
  • Odunayo A. Taiwo,
  • Temidayo O. Adigun,
  • Victoria O. Akomolafe,
  • Joshua O. Leigh,
  • Samson A. Rahman,
  • Ebenezer O. Farombi

摘要

Cisplatin (CISP) is a platinum-based xenobiotic used for treating various types of solid cancers. Like other anticancer drugs, CISP presents toxic side effects, which makes its chemotherapeutic use a futile effort. As part of this present study, the preliminary in silico molecular docking study carried out on syringic acid (SAC) revealed a close binding affinity of -4.5 kcal/mol compared with a known/documented activator recording a binding affinity of -4.6 kcal/mol. In the in vivo experiment, we therefore investigated the therapeutic and protective effects of SAC in CISP-induced testicular toxicity in rats, as a way of mitigating the latter’s side effect. The experimental setup involved 5 groups of 7 rats each: control, CISP (5 mg/kg) only, SAC (50 mg/kg) pre- and post-treatments, and SAC (50 mg/kg) only. Compared with the control group, CISP-induced gonadotoxicity was recorded, marked by a significant decrease in the serum levels of FSH, LH, testosterone, testis PI3K, NF-κB, and testis activities of GST and CAT. Also, a significant increase compared with the control in the levels of testis MDA, H2O2, GSH, testis protein expressions of p53 and caspase-3, and activities of testis GPx and SOD were seen. SAC treatments, especially the post-treatment, significantly ameliorated the effects of CISP-induced gonadotoxicity. Consequent upon the findings above, we concluded that the CISP-induced gonadotoxicity was tackled by SAC through its antioxidant property that counteracted the free radical production, lipid peroxidation, oxidative stress, and testicular apoptosis in rats.