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<p>Due to pressure to meet the ever-increasing demand for food crops and fruits, calcium carbide (CaC2), which is used for welding, desulfurizing steel, and synthesizing acetylene and cyanimide, has scrupulously obtained a function as a fruit-ripening agent. However, little is known about the cardiotoxicity profile of a diet supplemented with CaC2. This study investigated the cardiotoxicity effect of food supplemented with CaC2 in male Wistar rats. Twenty (20) male Wistar rats were randomly selected into 4 groups of 5 animals (n = 5) and fed with 0%, 10%, 20%, and 40% CaC2-supplemented diets, respectively, for 12&#xa0;weeks. The animals were sacrificed and the heart was harvested, homogenized, and centrifuged, and the resulting supernatant was used for biochemical assay. The result of this study revealed that 10%, 20%, and 40% CaC2-supplemented diets for 12&#xa0;weeks caused dyslipidemia, oxidative stress, inflammation, and apoptosis as well as elevated levels of cardiac CK-MB and troponin-I. CaC2-supplemented diet caused cardiometabolic dysfunction in male Wistar rat via mechanisms related to dyslipidemia, oxidative stress, and inflammation.</p>

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Cardiometabolic dysfunction is associated with calcium carbide intake in male Wistar rat: implication of dyslipidemia, oxidative stress, and inflammation

  • 期刊论文

  • 发表日期：

    2026年4月6日

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  • Jerome Ndudi Asiwe,
  • Akpevwoghene Agbatutu,
  • Nicholas Asiwe

摘要

Due to pressure to meet the ever-increasing demand for food crops and fruits, calcium carbide (CaC2), which is used for welding, desulfurizing steel, and synthesizing acetylene and cyanimide, has scrupulously obtained a function as a fruit-ripening agent. However, little is known about the cardiotoxicity profile of a diet supplemented with CaC2. This study investigated the cardiotoxicity effect of food supplemented with CaC2 in male Wistar rats. Twenty (20) male Wistar rats were randomly selected into 4 groups of 5 animals (n = 5) and fed with 0%, 10%, 20%, and 40% CaC2-supplemented diets, respectively, for 12 weeks. The animals were sacrificed and the heart was harvested, homogenized, and centrifuged, and the resulting supernatant was used for biochemical assay. The result of this study revealed that 10%, 20%, and 40% CaC2-supplemented diets for 12 weeks caused dyslipidemia, oxidative stress, inflammation, and apoptosis as well as elevated levels of cardiac CK-MB and troponin-I. CaC2-supplemented diet caused cardiometabolic dysfunction in male Wistar rat via mechanisms related to dyslipidemia, oxidative stress, and inflammation.