Scholarlink

<p>Cadmium exposure impairs renal function. This exposure disrupts serum electrolytes and trace element balance. This study aimed to determine whether an aqueous nettle (<i>Urtica dioica</i>) leaf extract alleviates cadmium chloride (CdCl₂)-induced kidney injury in male Wistar rats. The evaluation also tracked shifts in serum trace elements toward baseline. Forty male Wistar rats were randomized into four groups. The groups received a control, CdCl₂ at 5&#xa0;mg/kg/day via intraperitoneal injection, <i>Urtica dioica</i> extract at 100&#xa0;mg/kg/day via oral gavage or a co-administration. Treatments continued for 28 consecutive days. Assays measured serum urea, creatinine, and uric acid. Further tests quantified serum sodium, magnesium, iron, zinc, copper, and inorganic phosphate. Hematoxylin and eosin staining revealed kidney histopathology. Gas chromatography and mass spectrometry profiled the extract. CdCl₂ exposure increased renal function biomarkers and induced cortical tubular injury accompanied by interstitial inflammatory cell infiltration. Co-administration with the aqueous extract reduced the elevation of renal biomarkers, with serum creatinine decreasing from 0.80 ± 0.13 in the CdCl₂ group to 0.56 ± 0.06 in the co-administration group. Histopathological examination showed a corresponding reduction in lesion severity following co-administration. CdCl₂ exposure decreased serum iron and copper concentrations and increased sodium levels. Iron levels shifted toward baseline after co-administration, increasing from 129.25 ± 10.81 in the CdCl₂ group to 150.75 ± 18.72 in the co-administration group. Serum sodium remained higher than control values at 143.75 ± 1.97. Inorganic phosphate concentrations did not differ significantly among the experimental groups. An aqueous <i>Urtica dioica</i> leaf extract can alleviate renal dysfunction caused by exposure to cadmium chloride, and it also reduces the severity of histopathological tissue damage. The treatment partially restores the serum levels of trace elements.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Aqueous Urtica dioica leaf extract attenuates cadmium chloride-induced nephrotoxicity and shifts serum trace elements toward baseline in male Wistar rats

  • 期刊论文

  • 发表日期：

    2026年3月10日

查看全文
  • Maryam Ibrahim Salman,
  • Ibraheem Abdulnabi Shabeeb,
  • Fiham Jassim Al-Obaidi,
  • Omar M. Hasan,
  • Ali F. Almehemdi

摘要

Cadmium exposure impairs renal function. This exposure disrupts serum electrolytes and trace element balance. This study aimed to determine whether an aqueous nettle (Urtica dioica) leaf extract alleviates cadmium chloride (CdCl₂)-induced kidney injury in male Wistar rats. The evaluation also tracked shifts in serum trace elements toward baseline. Forty male Wistar rats were randomized into four groups. The groups received a control, CdCl₂ at 5 mg/kg/day via intraperitoneal injection, Urtica dioica extract at 100 mg/kg/day via oral gavage or a co-administration. Treatments continued for 28 consecutive days. Assays measured serum urea, creatinine, and uric acid. Further tests quantified serum sodium, magnesium, iron, zinc, copper, and inorganic phosphate. Hematoxylin and eosin staining revealed kidney histopathology. Gas chromatography and mass spectrometry profiled the extract. CdCl₂ exposure increased renal function biomarkers and induced cortical tubular injury accompanied by interstitial inflammatory cell infiltration. Co-administration with the aqueous extract reduced the elevation of renal biomarkers, with serum creatinine decreasing from 0.80 ± 0.13 in the CdCl₂ group to 0.56 ± 0.06 in the co-administration group. Histopathological examination showed a corresponding reduction in lesion severity following co-administration. CdCl₂ exposure decreased serum iron and copper concentrations and increased sodium levels. Iron levels shifted toward baseline after co-administration, increasing from 129.25 ± 10.81 in the CdCl₂ group to 150.75 ± 18.72 in the co-administration group. Serum sodium remained higher than control values at 143.75 ± 1.97. Inorganic phosphate concentrations did not differ significantly among the experimental groups. An aqueous Urtica dioica leaf extract can alleviate renal dysfunction caused by exposure to cadmium chloride, and it also reduces the severity of histopathological tissue damage. The treatment partially restores the serum levels of trace elements.