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<p>The objective of this study was to investigate the effects of <i>Nigella sativa</i> (black cumin) oil, known for its antioxidant and anti-inflammatory properties, on cytokine and antioxidant parameters in rats exposed to bisphenol A (BPA). BPA is widely recognized for its harmful effects on both human and environmental health. Specifically, the study focused on analyzing levels of TNF-α, IL-6, IL-10, malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD). The experimental design involved dividing rats into four equal groups: a control group (K), a <i>Nigella sativa</i> group (N), a BPA-only group, and a BPA plus <i>Nigella sativa</i> group (BPAN). The BPA and BPAN groups were administered 100&#xa0;mg/kg body weight of BPA. In addition, the N and BPAN groups received <i>Nigella sativa</i> oil orally at a dose of 5&#xa0;ml/kg body weight throughout the duration of the study. At the end of the experiment, rats in the BPA and BPAN groups showed significantly lower body weight compared to the control groups (K and N) (<i>p</i> &lt; 0.05). The BPA group exhibited a marked increase in MDA levels and a decrease in GSH levels compared to the other groups, indicating elevated oxidative stress (<i>p</i> &lt; 0.05). However, in the BPAN group, MDA levels showed a tendency to decrease, while GSH and SOD levels were notably increased compared to the BPA-only group. Regarding cytokine profiles, TNF-α and IL-6 levels were highest, and IL-10 levels were significantly lowest in the BPA group (<i>p</i> &lt; 0.05). In contrast, the BPAN group treated with <i>Nigella sativa</i> showed improvements in all these parameters, suggesting a modulating effect of the oil. This study was limited to adult male rats, with short-term BPA and Nigella sativa oil exposure, and a restricted set of biochemical and cytokine parameters, which may limit generalizability and interpretation of the results. The results clearly indicate that <i>Nigella sativa</i> oil has strong antioxidative and anti-inflammatory effects, effectively counteracting the oxidative stress and toxicity induced by BPA. These findings suggest that <i>Nigella sativa</i> oil may be beneficial in preventing or alleviating the harmful impacts of BPA exposure.</p>

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Nigella sativa the effect of seed oil on some cytokines and antioxidant system in bisphenol A–treated rats

  • 期刊论文

  • 发表日期：

    2026年2月17日

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  • Mesude Açıkbaş,
  • Ercan Keskin

摘要

The objective of this study was to investigate the effects of Nigella sativa (black cumin) oil, known for its antioxidant and anti-inflammatory properties, on cytokine and antioxidant parameters in rats exposed to bisphenol A (BPA). BPA is widely recognized for its harmful effects on both human and environmental health. Specifically, the study focused on analyzing levels of TNF-α, IL-6, IL-10, malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD). The experimental design involved dividing rats into four equal groups: a control group (K), a Nigella sativa group (N), a BPA-only group, and a BPA plus Nigella sativa group (BPAN). The BPA and BPAN groups were administered 100 mg/kg body weight of BPA. In addition, the N and BPAN groups received Nigella sativa oil orally at a dose of 5 ml/kg body weight throughout the duration of the study. At the end of the experiment, rats in the BPA and BPAN groups showed significantly lower body weight compared to the control groups (K and N) (p < 0.05). The BPA group exhibited a marked increase in MDA levels and a decrease in GSH levels compared to the other groups, indicating elevated oxidative stress (p < 0.05). However, in the BPAN group, MDA levels showed a tendency to decrease, while GSH and SOD levels were notably increased compared to the BPA-only group. Regarding cytokine profiles, TNF-α and IL-6 levels were highest, and IL-10 levels were significantly lowest in the BPA group (p < 0.05). In contrast, the BPAN group treated with Nigella sativa showed improvements in all these parameters, suggesting a modulating effect of the oil. This study was limited to adult male rats, with short-term BPA and Nigella sativa oil exposure, and a restricted set of biochemical and cytokine parameters, which may limit generalizability and interpretation of the results. The results clearly indicate that Nigella sativa oil has strong antioxidative and anti-inflammatory effects, effectively counteracting the oxidative stress and toxicity induced by BPA. These findings suggest that Nigella sativa oil may be beneficial in preventing or alleviating the harmful impacts of BPA exposure.