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<p>The current study aims to estimate the potential beneficial effects of melatonin on gasoline vapors (GV) exposition-induced hematological disorders and oxidative stress in rats. Twenty adult male rats were randomized into four groups and treated for 12 weeks: group I, control (C); group II, (GV) rats were exposed to gasoline fumes; group III, (MLT) rats received melatonin (10 mg/kg b.w.) intraperitoneally; and group IV, (PAH+MLT) rats were exposed to gasoline fumes and treated with melatonin (10 mg/kg b.w.). The GV exposure caused hematologic disorders evidenced by a decrease in white blood cells (WBCs), hemoglobin level (Hb), platelet count (PLT), and mean corpuscular volume (MCV), associated with a significantly increased plasma lactate dehydrogenase (LDH), creatine phosphokinase (CPK), triiodothyronine (T3), and thyroxin (T4) levels and a decrease in thyroid stimulating hormone (TSH) content. In addition, GV exposure led to liver oxidative damage indicated by an increase in malondialdehyde (MDA) contents, along with a decrease in the levels of reduced glutathione (GSH) and catalase (CAT) and glutathione-S-transferase (GST) activities. Overall, toxicity due to gasoline vapors exposure was high, but the response was resolved after melatonin. Supplementation of MLT improved biochemical and hormonal parameters and the antioxidant status. The thyroid and lung histological studies confirmed these changes, which support melatonin’s reparative effects.</p>

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The therapeutic potential of melatonin against gasoline vapor-induced oxidative stress and metabolic disorders in rats

  • 期刊论文

  • 发表日期：

    2026年1月24日

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  • Chekkal Raghda,
  • Lakbar Chanez,
  • Tichati Lazhari,
  • Trea Fouzia,
  • Ouali Kheireddine

摘要

The current study aims to estimate the potential beneficial effects of melatonin on gasoline vapors (GV) exposition-induced hematological disorders and oxidative stress in rats. Twenty adult male rats were randomized into four groups and treated for 12 weeks: group I, control (C); group II, (GV) rats were exposed to gasoline fumes; group III, (MLT) rats received melatonin (10 mg/kg b.w.) intraperitoneally; and group IV, (PAH+MLT) rats were exposed to gasoline fumes and treated with melatonin (10 mg/kg b.w.). The GV exposure caused hematologic disorders evidenced by a decrease in white blood cells (WBCs), hemoglobin level (Hb), platelet count (PLT), and mean corpuscular volume (MCV), associated with a significantly increased plasma lactate dehydrogenase (LDH), creatine phosphokinase (CPK), triiodothyronine (T3), and thyroxin (T4) levels and a decrease in thyroid stimulating hormone (TSH) content. In addition, GV exposure led to liver oxidative damage indicated by an increase in malondialdehyde (MDA) contents, along with a decrease in the levels of reduced glutathione (GSH) and catalase (CAT) and glutathione-S-transferase (GST) activities. Overall, toxicity due to gasoline vapors exposure was high, but the response was resolved after melatonin. Supplementation of MLT improved biochemical and hormonal parameters and the antioxidant status. The thyroid and lung histological studies confirmed these changes, which support melatonin’s reparative effects.