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<p>Dengue fever affects multiple body systems, including the heart, kidneys, liver, pancreas, eyes, and central nervous system. This study aimed to evaluate possible alterations in thyroid function among patients with dengue fever. Blood samples were collected from 50 laboratory-confirmed dengue patients (13 with severe dengue fever and 37 with dengue fever), and 40 age and sex-matched healthy individuals. T3, T4, and TSH levels were measured by using commercially available ELISA kits, and the data obtained were analyzed using One-Way ANOVA in the IBM-SPSS software. The intergroup comparison analysis, as revealed by One-Way ANOVA, indicated that the serum T3 level increased significantly (<i>p</i> = 0.008) in both dengue groups compared to controls. Similarly, the level of the T4 was significantly elevated in the dengue groups compared to controls (<i>p</i> &lt; 0.001). However, there was a significant (<i>p</i> &lt; 0.001) decrease in TSH serum levels in dengue groups compared to controls. Our findings indicate that dengue infection is associated with disruption in thyroid hormone regulation, which may contribute to metabolic complications.</p>

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Alterations in thyroid profile in dengue fever patients: a case-control study

  • 期刊论文

  • 发表日期：

    2026年1月27日

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  • Humera Naveed,
  • Kaleem Maqsood,
  • Husna Ahmad,
  • Waheed Haider,
  • Muhammad Amir Iqbal,
  • Nabila Roohi

摘要

Dengue fever affects multiple body systems, including the heart, kidneys, liver, pancreas, eyes, and central nervous system. This study aimed to evaluate possible alterations in thyroid function among patients with dengue fever. Blood samples were collected from 50 laboratory-confirmed dengue patients (13 with severe dengue fever and 37 with dengue fever), and 40 age and sex-matched healthy individuals. T3, T4, and TSH levels were measured by using commercially available ELISA kits, and the data obtained were analyzed using One-Way ANOVA in the IBM-SPSS software. The intergroup comparison analysis, as revealed by One-Way ANOVA, indicated that the serum T3 level increased significantly (p = 0.008) in both dengue groups compared to controls. Similarly, the level of the T4 was significantly elevated in the dengue groups compared to controls (p < 0.001). However, there was a significant (p < 0.001) decrease in TSH serum levels in dengue groups compared to controls. Our findings indicate that dengue infection is associated with disruption in thyroid hormone regulation, which may contribute to metabolic complications.