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<p>Millions of children and women are affected by anemia world-wide every year. The most common anemia causes are iron deficiency anemia (IDA) and thalassemia trait (TT). Thalassemia distribution extends mainly from the Mediterranean area to Southeast Asia with unclear prevalence in Egypt. Irregular iron supplementation is common in Egypt as a usual medical practice in pediatrics. The aim of this study is to assess the performance of different complete blood count indices to differentiate between IDA and BTT in Egyptian children in spite of irregular iron supplementations to minimize the cost of screening in low- and middle-income countries (LMIC) as Egypt. A cross-sectional observational study was conducted in Mansoura Children Hospital, Mansoura University, Egypt. Complete blood count, iron profile, and capillary hemoglobin electrophoresis were performed on all subjects. There is a significant reduction of RBCs count, transferrin saturation, and ferritin in the IDA group compared to the thalassemia group, while platelet count, MCV, MCH, and RDW show a significant increase in IDA in comparison with the BTT group. RBCs count (78.4%) and the England and Fraser (78.4%) indices were the best to correctly differentiate between IDA and TT, followed by the Srivastava (77.3%) and the Green and King (77.3%) indices. The RBCs count index showed the best assessed screening tool to differentiate between IDA and TT in Egyptian children on irregular iron therapy. Youden’s index for all calculated CBC indices showed a dramatic decrement. These results reflect the importance of limiting the variables affecting CBC to keep its efficacy.</p>

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Performance of complete blood count indices in differentiating between iron deficiency anemia and beta thalassemia trait in Egyptian children

  • 期刊论文

  • 发表日期：

    2026年2月3日

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  • Rana Mohamed Shaat,
  • Omnia Khaled Zakaria,
  • Ahmad Mohamed Darwish,
  • Mai shawky Korkor,
  • Amr Mohamed Fathy,
  • Ahmed Saad Almenshawy

摘要

Millions of children and women are affected by anemia world-wide every year. The most common anemia causes are iron deficiency anemia (IDA) and thalassemia trait (TT). Thalassemia distribution extends mainly from the Mediterranean area to Southeast Asia with unclear prevalence in Egypt. Irregular iron supplementation is common in Egypt as a usual medical practice in pediatrics. The aim of this study is to assess the performance of different complete blood count indices to differentiate between IDA and BTT in Egyptian children in spite of irregular iron supplementations to minimize the cost of screening in low- and middle-income countries (LMIC) as Egypt. A cross-sectional observational study was conducted in Mansoura Children Hospital, Mansoura University, Egypt. Complete blood count, iron profile, and capillary hemoglobin electrophoresis were performed on all subjects. There is a significant reduction of RBCs count, transferrin saturation, and ferritin in the IDA group compared to the thalassemia group, while platelet count, MCV, MCH, and RDW show a significant increase in IDA in comparison with the BTT group. RBCs count (78.4%) and the England and Fraser (78.4%) indices were the best to correctly differentiate between IDA and TT, followed by the Srivastava (77.3%) and the Green and King (77.3%) indices. The RBCs count index showed the best assessed screening tool to differentiate between IDA and TT in Egyptian children on irregular iron therapy. Youden’s index for all calculated CBC indices showed a dramatic decrement. These results reflect the importance of limiting the variables affecting CBC to keep its efficacy.