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<p>The extensive production of organic UV filters has resulted in the entry of these emerging contaminants into the aquatic environment and adversely affected the aquatic organisms. Among the UV filters, octocrylene (OC), is widely used to protect against the harmful effects of UV radiation in many consumer products. As a result, octocrylene (OC) has been detected in many environmental matrices and biota. Despite many studies on octocrylene (OC) toxicity to aquatic organisms, data on the impact of octocrylene (OC) on growth and thyroid hormones in aquatic organisms such as fish are very limited. This study aimed to investigate the influence of octocrylene-induced thyroid and growth hormone effects in zebrafish to elucidate the underlying mechanisms <i>in&#xa0;vivo</i>. In this study, zebrafish (<i>Danio rerio</i>) larvae were exposed to different concentrations (5, 50 and 500&#xa0;μg/L) of octocrylene (OC) for 96&#xa0;h. Growth hormone and thyroid hormones (T3 and T4) responses were assessed to evaluate the impact of organic UV filter octocrylene. We have used ELISA kid to analyze the hormonal effect in zebrafish larvae. Our results showed that the growth was significantly (<i>P</i> &lt; 0.05) decreased in all the concentrations. Likewise, thyroid hormones (T3 and T4) were also decreased in all the concentrations when compared to the control group. A concentration-dependent decrease in growth and thyroid hormones was noted throughout the study period (96&#xa0;h). The findings of the present study indicate that octocrylene (OC) at tested concentrations altered the hormonal activities of the fish and the changes in the hormonal levels can be used as a potential biomarker for monitoring of octocrylene (OC) in aquatic environments.</p>

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Acute toxicity assessment of organic UV filter octocrylene in the early life stages of zebrafish (Danio rerio): growth and thyroid hormone responses

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • Murugesh Gayathri,
  • Jesudass Sutha,
  • Sundaram Mohanthi,
  • Mathan Ramesh

摘要

The extensive production of organic UV filters has resulted in the entry of these emerging contaminants into the aquatic environment and adversely affected the aquatic organisms. Among the UV filters, octocrylene (OC), is widely used to protect against the harmful effects of UV radiation in many consumer products. As a result, octocrylene (OC) has been detected in many environmental matrices and biota. Despite many studies on octocrylene (OC) toxicity to aquatic organisms, data on the impact of octocrylene (OC) on growth and thyroid hormones in aquatic organisms such as fish are very limited. This study aimed to investigate the influence of octocrylene-induced thyroid and growth hormone effects in zebrafish to elucidate the underlying mechanisms in vivo. In this study, zebrafish (Danio rerio) larvae were exposed to different concentrations (5, 50 and 500 μg/L) of octocrylene (OC) for 96 h. Growth hormone and thyroid hormones (T3 and T4) responses were assessed to evaluate the impact of organic UV filter octocrylene. We have used ELISA kid to analyze the hormonal effect in zebrafish larvae. Our results showed that the growth was significantly (P < 0.05) decreased in all the concentrations. Likewise, thyroid hormones (T3 and T4) were also decreased in all the concentrations when compared to the control group. A concentration-dependent decrease in growth and thyroid hormones was noted throughout the study period (96 h). The findings of the present study indicate that octocrylene (OC) at tested concentrations altered the hormonal activities of the fish and the changes in the hormonal levels can be used as a potential biomarker for monitoring of octocrylene (OC) in aquatic environments.