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<p>Coenurosis is a fatal disease caused by the larval stage of <i>Taenia multiceps</i>, resulting in significant economic losses in sheep production worldwide. The larvae invade the central nervous system of various intermediate hosts, including sheep, goats, cattle, and even humans, typically through ingestion of contaminated feed. Cellular and biochemical parameters, especially antioxidant and oxidative stress markers, in cerebrospinal fluid (CSF) and blood serum are valuable diagnostic indicators in affected sheep. The aim of this study was to evaluate antioxidant and oxidant markers in the serum and CSF of sheep with Coenurosis and to compare these parameters with a healthy control group. A total of eleven sheep diagnosed with Coenurosis and four healthy sheep were ethically enrolled in the study. Blood samples were collected from the jugular vein, and CSF was obtained via a lumbosacral puncture. Antioxidant activities were measured using Zellbio kits, and the results are presented as mean ± standard deviation. Significantly increased malondialdehyde (MDA) levels (*<i>p</i>* &lt; 0.05) were observed in the CSF of affected sheep (7.05 ± 0.67 μmol), compared to healthy controls (5.35 ± 0.52 μmol). Similarly, glutathione peroxidase (GSHPx) activity in CSF was significantly lower in infected animals (112 ± 19.99 U/ml) than in controls (127 ± 13.89 U/ml). No statistically significant differences were detected in the serum samples. Notably, other measured antioxidant parameters—including catalase, superoxide dismutase, and total antioxidant capacity—did not show significant differences between groups. In conclusion, decreased GSHPx and increased MDA levels in CSF may serve as potential biochemical markers for the diagnosis of Coenurosis in sheep, aiding veterinary practitioners in early detection and management of the disease.</p>

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The study of antioxidant and lipid peroxidation levels in blood serum and cerebrospinal fluid of healthy sheep and sheep affected by Coenurus cerebralis

  • 期刊论文

  • 发表日期：

    2025年7月2日

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  • Amin Anoushepour,
  • Erfan Frounchi,
  • Seyedeh Parastoo Yasini,
  • Javad Abbasi

摘要

Coenurosis is a fatal disease caused by the larval stage of Taenia multiceps, resulting in significant economic losses in sheep production worldwide. The larvae invade the central nervous system of various intermediate hosts, including sheep, goats, cattle, and even humans, typically through ingestion of contaminated feed. Cellular and biochemical parameters, especially antioxidant and oxidative stress markers, in cerebrospinal fluid (CSF) and blood serum are valuable diagnostic indicators in affected sheep. The aim of this study was to evaluate antioxidant and oxidant markers in the serum and CSF of sheep with Coenurosis and to compare these parameters with a healthy control group. A total of eleven sheep diagnosed with Coenurosis and four healthy sheep were ethically enrolled in the study. Blood samples were collected from the jugular vein, and CSF was obtained via a lumbosacral puncture. Antioxidant activities were measured using Zellbio kits, and the results are presented as mean ± standard deviation. Significantly increased malondialdehyde (MDA) levels (*p* < 0.05) were observed in the CSF of affected sheep (7.05 ± 0.67 μmol), compared to healthy controls (5.35 ± 0.52 μmol). Similarly, glutathione peroxidase (GSHPx) activity in CSF was significantly lower in infected animals (112 ± 19.99 U/ml) than in controls (127 ± 13.89 U/ml). No statistically significant differences were detected in the serum samples. Notably, other measured antioxidant parameters—including catalase, superoxide dismutase, and total antioxidant capacity—did not show significant differences between groups. In conclusion, decreased GSHPx and increased MDA levels in CSF may serve as potential biochemical markers for the diagnosis of Coenurosis in sheep, aiding veterinary practitioners in early detection and management of the disease.