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<p>This study investigates the phytochemical profile, antioxidant properties, and antidiabetic potential of <i>Ziziphus nummularia</i>, a traditional plant extensively used in folk medicine. Phytochemical screening was conducted to identify bioactive compounds, revealing the presence of flavonoids, alkaloids, tannins, saponins, and phenolic compounds known for their pharmacological activities. The antioxidant activity was assessed using DPPH, reducing power, hydrogen peroxide scavenging activity, phosphomolybdate assay, hydroxyl radical scavenging assays, etc., showing significant free radical inhibition, underscoring its potential to mitigate oxidative stress–related complications. The antidiabetic effect was evaluated through OGTT, and alloxan monohydrate (150&#xa0;mg/kg, i.p.) induced diabetes in mice. The effect of vehicle, extract (100, 200, and 400&#xa0;mg/kg), and Glibenclamide (l0 mg/kg) on blood glucose, body weight, lipid levels, and kidney function tests was observed. The histopathology of the pancreas and kidney showed significant restoration of their functions. These results suggest that <i>Ziziphus nummularia</i> holds promise as a natural antioxidant and antidiabetic agent, with potential applications in developing plant-based therapies for diabetes and oxidative stress–related diseases. Further in vivo studies and bioactivity-guided isolation of active constituents are recommended to validate and optimize its therapeutic efficacy.</p> Graphical Abstract <p></p>

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Phytochemical screening, antioxidant and antidiabetic potential of Ziziphus nummularia

  • 期刊论文

  • 发表日期：

    2025年5月19日

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  • Sapna Bhardwaj,
  • Rupali Chauhan,
  • Manjusha Chaudhary,
  • Dhirender Kaushik,
  • Ravinder Singh

摘要

This study investigates the phytochemical profile, antioxidant properties, and antidiabetic potential of Ziziphus nummularia, a traditional plant extensively used in folk medicine. Phytochemical screening was conducted to identify bioactive compounds, revealing the presence of flavonoids, alkaloids, tannins, saponins, and phenolic compounds known for their pharmacological activities. The antioxidant activity was assessed using DPPH, reducing power, hydrogen peroxide scavenging activity, phosphomolybdate assay, hydroxyl radical scavenging assays, etc., showing significant free radical inhibition, underscoring its potential to mitigate oxidative stress–related complications. The antidiabetic effect was evaluated through OGTT, and alloxan monohydrate (150 mg/kg, i.p.) induced diabetes in mice. The effect of vehicle, extract (100, 200, and 400 mg/kg), and Glibenclamide (l0 mg/kg) on blood glucose, body weight, lipid levels, and kidney function tests was observed. The histopathology of the pancreas and kidney showed significant restoration of their functions. These results suggest that Ziziphus nummularia holds promise as a natural antioxidant and antidiabetic agent, with potential applications in developing plant-based therapies for diabetes and oxidative stress–related diseases. Further in vivo studies and bioactivity-guided isolation of active constituents are recommended to validate and optimize its therapeutic efficacy.

Graphical Abstract