Cardio-protective effects of naringin against lipopolysaccharide-induced oxidative stress and chronic inflammation in SD rats

In the pathogenesis of heart disease, oxidative stresses, inflammations, and vascular dysfunction are interconnected components. The goal of the current investigation was to determine how naringin could reduce oxidative stress, inflammation, and vascular dysfunction in rats that received LPS. Lipopolysaccharide (LPS) was injected into a rat’s tail vein once a week for 6 weeks in order to establish chronic vascular inflammation and oxidative stress. Endothelial activity was considerably reduced in LPS group animals compared to normal control, as well as endothelial performances were dependently improved by naringin therapy. Nevertheless, there was an augmentation in aortic superoxide dismutase (SOD) function, nitric oxide (NO) concentration, and constitutive nitric oxide synthase (cNOS) activity, while reduction in aortic malondialdehyde (MDA) levels and inducible nitric oxide synthase (iNOS) activity. These findings suggest that long-term naringin therapy may help to avoid cardiovascular challenges posed by endothelial dysfunction.