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<p>Tropical regions bear the main burden because malaria continues to be a major health risk throughout the world. The timely, precise diagnosis of malaria at each stage of the disease proves essential for proper treatment as well as disease control efforts. This research develops a sensitivity-enhanced nanostructured plasmonic biosensor that employs a metal-insulator-metal waveguide-resonator architecture for malaria detection. The performance of the sensor reached significant enhancement after optimizing the waveguide width to 50&#xa0;nm, the resonator width to 60&#xa0;nm, and the resonator length to 370&#xa0;nm. The transmission spectra for specific stages of infection demonstrated pronounced resonance phenomena in the Ring stage, along with the Trophozoite and Schizont stages. The Trophozoite stage exhibited the highest sensitivity of 937.04&#xa0;nm/RIU, together with a quality factor of 37.56 and a figure of merit of 46.16 RIU⁻¹. The proposed device demonstrates promising and competitive performance based on its optimized sensitivity, QF, and FOM, while offering potential for future label-free, non-invasive, and real-time malaria detection after experimental validation. The proposed device structure maintains simplicity while being suitable for point-of-care platforms, thus indicating its strong potential to operate in low-resource environments.</p>

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Design and optimization of a nanostructured MIM plasmonic biosensor for stage-specific malaria detection

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Huifang Chen,
  • Pingliang Ding

摘要

Tropical regions bear the main burden because malaria continues to be a major health risk throughout the world. The timely, precise diagnosis of malaria at each stage of the disease proves essential for proper treatment as well as disease control efforts. This research develops a sensitivity-enhanced nanostructured plasmonic biosensor that employs a metal-insulator-metal waveguide-resonator architecture for malaria detection. The performance of the sensor reached significant enhancement after optimizing the waveguide width to 50 nm, the resonator width to 60 nm, and the resonator length to 370 nm. The transmission spectra for specific stages of infection demonstrated pronounced resonance phenomena in the Ring stage, along with the Trophozoite and Schizont stages. The Trophozoite stage exhibited the highest sensitivity of 937.04 nm/RIU, together with a quality factor of 37.56 and a figure of merit of 46.16 RIU⁻¹. The proposed device demonstrates promising and competitive performance based on its optimized sensitivity, QF, and FOM, while offering potential for future label-free, non-invasive, and real-time malaria detection after experimental validation. The proposed device structure maintains simplicity while being suitable for point-of-care platforms, thus indicating its strong potential to operate in low-resource environments.